Clinical efficacy of two single inhalers combined with three therapeutic drugs in treating patients with severe chronic obstructive pulmonary disease

ZHU Yujin; MIAO Hui; QIAO Zhi; CHEN Yibing; HAN Guojing

doi:10.3969/j.issn.1004-3594.2026.07.004

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Medical Journal of the Chinese People Armed Police Forces ›› 2026, Vol. 37 ›› Issue (7) : 569-574. DOI: 10.3969/j.issn.1004-3594.2026.07.004

ORIGINAL ARTICLES

Clinical efficacy of two single inhalers combined with three therapeutic drugs in treating patients with severe chronic obstructive pulmonary disease

ZHU Yujin^1,2, MIAO Hui³, QIAO Zhi⁴, CHEN Yibing², HAN Guojing²

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Abstract

Objective To compare the clinical efficacy of fluticasone/umeclidinium/vilanterol(FF/UMEC/VI) inhalation powder and budesonide/glycopyrrolate/formoterol (BUD/GLY/FOR) inhalation aerosol in the treatment of severe chronic obstructive pulmonary disease (COPD) based on symptom scores and health status. Methods A total of 66 patients with severe COPD were retrospectively selected and divided into a FF/UMEC/VI group and a BUD/GLY/FOR group. The health status and symptom scores of the two groups were compared at 1 month of single inhaler triple therapy (SITT) drug use, and the short-term and long-term symptom changes of the FF/UMEC/VI group were retrospectively analyzed. Results The FF/UMEC/VI group had 35 patients, and the BUD/GLY/FOR group had 31 patients. Compared with before treatment, there was significant improvement in COPD assessment test (CAT) score, mMRC score, and 6MWT at 1 month of treatment in both groups, and the differences were statistically significant (P<0.05). Compared with the BUD/GLY/FOR group, the mMRC score (U=-2.277, P<0.05)and 6MWT (U=-3.993,P<0.05) of the FF/UMEC/VI group improved at 1 month of treatment, with statistically significant differences. In the FF/UMEC/VI group, the symptom score and health status improved more at 8 months of maintenance treatment than at 3 months, but the difference was not statistically significant. Conclusions At 1 month of treatment, FF/UMEC/VI inhalation powder is superior to BUD/GLY/FOR inhalation aerosol in improving the symptom scores and health status of the patients with severe COPD.

Key words

FF/UMEC/VI / BUD/GLY/FOR / CAT score / mMRC score / 6MWT

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ZHU Yujin, MIAO Hui, QIAO Zhi, CHEN Yibing, HAN Guojing. Clinical efficacy of two single inhalers combined with three therapeutic drugs in treating patients with severe chronic obstructive pulmonary disease[J]. Medical Journal of the Chinese People Armed Police Forces. 2026, 37(7): 569-574 https://doi.org/10.3969/j.issn.1004-3594.2026.07.004

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