Differential diagnostic value of pepsinogen and gastrin levels on autoimmune gastritis and Hp-associated atrophic gastritis

WEI Xiaoyan; LI Yingxia; ZHANG Lili; CHENG Beibei; SU Liting

doi:10.3969/j.issn.1004-3594.2026.08.004

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Medical Journal of the Chinese People Armed Police Forces ›› 2026, Vol. 37 ›› Issue (8) : 669-674. DOI: 10.3969/j.issn.1004-3594.2026.08.004

ORIGINAL ARTICLES

Differential diagnostic value of pepsinogen and gastrin levels on autoimmune gastritis and Hp-associated atrophic gastritis

WEI Xiaoyan¹, LI Yingxia², ZHANG Lili¹, CHENG Beibei¹, SU Liting¹

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Abstract

Objective To explore the differential diagnostic value of pepsinogen and gastrin in patients with autoimmune gastritis(AIG)and helicobacter pylori (Hp)-associated atrophic gastritis. Methods A retrospective analysis was conducted on clinical data of 115 patients diagnosed with AIG (AIG group) in Henan Provincial Corps Hospital of Chinese People's Armed Police Force from January 2022 to December 2025. Additionally,108 patients with Hp-associated atrophic gastritis (Hp-associated atrophic gastritis group) and 100 healthy individuals (healthy group) were selected for comparison. The differences in general features, serum levels of pepsinogen I and II, and gastrin among the three groups were analyzed to assess the differential diagnostic value on pepsinogen and gastrin in differentiating AIG from Hp-associated atrophic gastritis. Results Females accounted for 56.52% of the AIG group, significantly higher than those in the Hp-associated atrophic gastritis group and the healthy group (P<0.05). The level of pepsinogen I in the AIG group was (15.56±5.56) μg/L, which was markedly lower than those in in the other two groups (P<0.05), while, the gastrin level was (183.34±72.23) ng/L, significantly higher than those in the other two groups (P<0.05). The level of pepsinogen Ⅱ in the AIG group was (7.10±2.12) μg/L, which was lower than that in the healthy group (P<0.05), but showed no statistically significant difference compared with the Hp-associated atrophic gastritis group. The receiver operating characteristic (ROC) curve analysis revealed that the areas under the ROC curves for pepsinogen I and gastrin in differentiating AIG from HP-associated atrophic gastritis were 0.871 (95% CI: 0.822-0.920) and 0.899 (95% CI: 0.858-0.940), respectively, both showing statistical significance (P<0.001). Conclusions Serum levels of pepsinogen I and gastrin differ significantly between AIG and Hp-associated atrophic gastritis patients, indicating that pepsinogen I and gastrin have good differential diagnostic value for these two diseases.

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autoimmune gastritis / helicobacter pylori associated atrophic gastritis / pepsinogen / gastrin / differential diagnostic value

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WEI Xiaoyan, LI Yingxia, ZHANG Lili, CHENG Beibei, SU Liting. Differential diagnostic value of pepsinogen and gastrin levels on autoimmune gastritis and Hp-associated atrophic gastritis[J]. Medical Journal of the Chinese People Armed Police Forces. 2026, 37(8): 669-674 https://doi.org/10.3969/j.issn.1004-3594.2026.08.004

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