Objective To analyze the risk factors of osteoporosis(OP) in postmenopausal women and investigate the correlation between bone turnover biomarkers (BTMs) and bone mineral density (BMD). Methods A cross-sectional study was conducted on 273 postmenopausal women who participated in a health education program in a community of Beijing from April to December 2013. According to the WHO diagnostic criteria, the participants were divided into an OP group (101 cases) and a non-OP group (172 cases). General data, biochemical indicators and BTMs were collected, and dual-energy X-ray BMD was measured. Results The prevalence of OP in the postmenopausal women was 37.0%, which significantly increased with age (15.4% for <50 years old; 29.9% for 50-64 years old; 47.2% for ≥65 years old). Compared with the non-OP group, the OP group was older, and had a longer menopause duration, lower height, weight and body mass index (BMI), and higher levels of serum alkaline phosphatase (ALP) and osteocalcin (OC) (P＜0.05). Correlation analysis revealed that lumbar BMD was positively correlated with height, weight and BMI, and negatively correlated with age, menopause duration, ALP, blood calcium, OC and type I collagen carboxy-terminal peptide (CTX) (P＜0.05). The correlation patterns of BMD in different sites with various indicators were different: lumbar BMD showed a stronger association with metabolic indicators, while proximal femoral BMD had a stronger correlation with mechanical factors. Logistic regression analysis identified menopause duration (OR=1.091, 95%CI: 1.001-1.181), ALP (OR=1.028, 95%CI: 1.006-1.047) and OC (OR=1.037, 95%CI: 1.002-1.071) as independent risk factors for OP. Conclusions Menopause duration, ALP, and OC are independent risk factors for OP in postmenopausal women. The correlation patterns of BMD in different sites with clinical indicators are different. Comprehensive use of these available indicators may facilitate the early identification and stratified management of high-risk OP populations in a community.
Key words
postmenopausal women /
osteoporosis /
bone mineral density /
bone turnover biomarkers /
risk factors
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