Objective To analyze the correlation between atherogenic index of plasma (AIP) and small and dense low-density lipoprotein cholesterol (sdLDL-C) in community population, and to explore the clinical application value of AIP in community physical examinations. Methods A total of 721 residents from Daxing District of Beijing who participated in physical examinations from January to October 2018 were selected. General information, fasting blood glucose (FBG) and blood lipid indexes were collected. The subjects were grouped according to AIP quartile, and the baseline characteristics of each group were compared. Spearman correlation analysis was performed to evaluate the correlation between AIP and each index. Logistic regression analysis was employed to analyze the relationship between AIP, sdLDL-C and the elevated FBG (defined as FBG≥6.1 mmol/L), meanwhile adjustments were made on confounding factors such as gender, age, body mass index (BMI), smoking and alcohol consumption. Results With the increase of AIP quartile, BMI, FBG and sdLDL-C significantly increased, while HDL-C significantly decreased (P＜0.01). Correlation analysis showed that AIP was significantly positively correlated with sdLDL-C (P＜0.01). Logistic regression results showed that compared with AIP Q1 group, the risk of elevated FBG of Q3 group (OR=2.03,95% CI:1.26-3.26,P=0.003) and Q4 group (OR=2.64,95% CI:1.63-4.27, P＜0.001) significantly increased after the adjustment of confounding factors. In the adjusted group, sdLDL-C showed independent correlation with AIP in Q4 group (OR=2.19,95% CI:1.38-3.47,P=0.001). Conclusions There is a significant positive correlation between AIP and sdLDL-C in the community population, and both are significantly related to the elevated FBG. As a simple and readily available calculation index, AIP can partially replace sdLDL-C when detection of the latter is unavailable, and can be used to identify individuals with abnormal glucose and lipid metabolism and high risk of atherosclerosis.
Key words
community population /
atherosclerosis index of plasma /
small and dense low-density lipoprotein cholesterol /
elevated fasting blood glucose /
correlation
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References
[1] 王增武,刘 静,李建军,等.中国血脂管理指南(2023年)[J].中国循环杂志,2023,38(3):237-271.
[2] Dobiásová M,Frohlich J.The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma[J].Clin Biochem, 2001,34(7):583-588.
[3] Zhang N,Xie G,Jian G,et al.Association of cumulative changes in atherogenic index of plasma and its obesity-related derivatives with cardiovascular disease: emphasis on incremental risk of diabetes status[J].Cardiovasc Diabetol,2025,24(1):435.
[4] Zhang J,Suo Y,Wang L,et al.Association between atherogenic index of plasma and gestational diabetes mellitus: a prospective cohort study based on the Korean population[J].Cardiovasc Diabetol,2024,23(1):237.
[5] Kurklu H A,Tan T S,Ozyuncu N,et al.Atherogenic index of plasma predicts obstructive coronary artery disease in patients with stable angina pectoris[J].Diagnostics,2023,13(20):3249.
[6] 中华医学会糖尿病学分会,国家基层糖尿病防治管理办公室.国家基层糖尿病防治管理指南(2022)[J].中华内科杂志,2022,61(3):249-262.
[7] 刘志远,谷 春,任 鹏,等.北京市大兴区成人空腹血糖受损现状调查[J].武警医学,2023,34(5):413-416.
[8] Liou L,Kaptoge S.Association of small, dense LDL-cholesterol concentration and lipoprotein particle characteristics with coronary heart disease: a systematic review and meta-analysis[J].PLoS One,2020,15(11): e0241993.
[9] Ikezaki H,Lim E,Cupples L A,et al.Small dense low-density lipoprotein cholesterol is the most atherogenic lipoprotein parameter in the prospective framingham offspring study[J].J Am Heart Assoc,2021,10(5):e019140.
[10] Hoogeveen R C,Gaubatz J W,Sun W,et al.Small dense low-density lipoprotein-cholesterol concentrations predict risk for coronary heart disease: the Atherosclerosis Risk In Communities (ARIC) study[J].Arterioscler Thromb Vasc Biol,2014,34(5):1069-1077.
[11] Higashioka M,Sakata S,Honda T,et al.Small dense low-density lipoprotein cholesterol and the risk of coronary heart disease in a Japanese community[J].J Atheroscler Thromb,2020,27(7):669-682.
[12] Dabravolski S,Orekhov N A,Melnichenko A,et al.Cholesteryl Ester Transfer Protein (CETP) variations in relation to lipid profiles and cardiovascular diseases: an update[J].Curr Pharm Des,2024,30(10):742-756.
[13] He Q,Wang L,Fang Y,et al.Relationship of small dense low-density lipoprotein cholesterol level with pre-diabetes and newly detected type 2 diabetes[J].Sci Rep,2025,15(1):19500.
[14] Wang T,Zhang M,Shi W,et al.Atherogenic index of plasma, high sensitivity C-reactive protein and incident diabetes among middle-aged and elderly adults in China: a national cohort study[J].Cardiovasc Diabetol,2025, 24(1):103.
[15] Gao Y.Association of estimated small dense low-density lipoprotein cholesterol with diabetes mellitus: a large-scale multicenter retrospective cohort study[J].BMC Endocr Disord,2025,25(1):66.
[16] Hirano T.Clinical significance of small dense low-density lipoprotein cholesterol measurement in type? 2 diabetes[J].J Diabetes Investig,2025,16(3):370-383.
[17] Zhang F,Zhang Y,Zhang J,et al.Small dense low density lipoprotein predominance in patients with type 2 diabetes mellitus using Mendelian randomization[J].PLoS One,2024,19(2):e0298070.
[18] Balling M,Nordestgaard B G,Varbo A,et al.Small dense low-density lipoprotein cholesterol and ischemic stroke[J].Ann Neurol,2023,93(5):952-964.
[19] Ichikawa T,Okada H,Hamaguchi M,et al.Estimated small dense low-density lipoprotein-cholesterol and incident type 2 diabetes in Japanese people: population-based panasonic cohort study[J].Diabetes Res Clin Pract, 2023,199:110665.
[20] Bekbossynova M,Saliev T,Ivanova R T,et al.Small dense LDL: an underestimated driver of atherosclerosis (Review)[J].Mol Med Rep,2025,32(6):328.
[21] Tao Y,Wang T,Zhou W,et al. Association between nontraditional lipid profiles and the risk of type 2 diabetes mellitus in Chinese adults with hypertension: findings from the China hypertension registry study[J].J Clin Hypertens,2025,27(1):e14927.
[22] Qu L,Fang S,Lan Z,et al.Association between atherogenic index of plasma and new-onset stroke in individuals with different glucose metabolism status: insights from CHARLS[J].Cardiovasc Diabetol,2024,23(1):215.
[23] Wang X,Wen P,Liao Y,et al.Association of atherogenic index of plasma and its modified indices with stroke risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: a longitudinal analysis based on CHARLS[J].Cardiovasc Diabetol,2025,24(1):254.
[24] Min Q,Wu Z,Yao J,et al.Association between atherogenic index of plasma control level and incident cardiovascular disease in middle-aged and elderly Chinese individuals with abnormal glucose metabolism[J]. Cardiovasc Diabetol,2024,23(1):54.
[25] Rashidian P,Mirchandani M,Somu K P,et al.Association between atherogenic index of plasma and various metabolic conditions: an umbrella review on meta-analyses[J].BMC Cardiovasc Disord,2025,26(1):41.
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