Objective To explore the clinical efficacy of Juanbi plaster combined with conventional western medicine in the treatment of post-traumatic knee osteoarthritis and its effect on inflammatory markers. Methods A total of 118 patients with traumatic knee osteoarthritis treated in the outpatient and inpatient departments of the Traditional Chinese Medicine Department of General Hospital of PLA Eastern Theater Command from November 2024 to November 2025 were selected and randomly divided into a control group (treated with nonsteroidal anti-inflammatory drugs, NSAIDs) and an observation group (treated with Juanbi plaster acupoint application based on NSAIDs), with 59 cases in each group. A total of 10 patients were excluded due to loss to follow-up and poor compliance, and 108 cases were finally included (50 in the control group and 58 in the observation group). The clinical efficacy, Visual Analogue Scale (VAS) pain scores, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores, and Lysholm knee scores before and after treatment were analyzed in both groups. Results The proportions of clinical control and marked effectiveness in the observation group were significantly higher than those in the control group, and there was a significant linear trend in efficacy distribution (P<0.05). After treatment, the VAS pain scores, total scores of WOMAC, and Lysholm knee joint scores of both groups were lower than those before treatment, and the differences were statistically significant (P<0.05).Compared with the control group, the observation group showed significantly greater reduction in VAS pain scores, WOMAC scores, functional scores and Lysholm knee joint scores, with statistically significant differences (P<0.05), especially the reduction in VAS pain score during the acute phase,which decreased more significantly,with statistically significant differences (P<0.05).Regarding inflammatory markers, the levels of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin-6 (IL-6), and procalcitonin (PCT) decreased significantly in both groups after treatment (P<0.05); the reduction in the observation group was more significant than that in the control group, with statistically significant differences (P<0.05). Conclusions Juanbi plaster combined with conventional western medicine can relieve the joint pain and promote the functional recovery of the knee joint in patients with traumatic knee arthritis.
Key words
Juanbi plaster /
non-steroidal anti-inflammatory drugs /
acupoint application /
post-traumatic knee osteoarthritis;inflammatory markers
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References
[1] Panchal N K, Prince Sabina E. Non-steroidal anti-inflammatory drugs (NSAIDs): a current insight into its molecular mechanism eliciting organ toxicities[J]. Food Chem Toxicol, 2023, 172: 113598.
[2] 王宏伟,余 磊,赵宝峰. 塞来昔布治疗膝骨关节炎的临床疗效及其机制[J]. 武警医学, 2023, 34 (10): 829-832.
[3] 赵大伟,姚太顺,郭跃生,等. 中药外洗联合玻璃酸钠关节腔注射治疗踝关节创伤性关节炎临床研究[J]. 陕西中医, 2018, 39 (5): 621-624.
[4] 李晨曦,戴致波,邢增宇,等. 自拟活血通利汤联合金黄跌打散外敷治疗气滞血瘀型急性膝关节创伤性滑膜炎临床观察[J]. 中医药临床杂志, 2020, 32 (6): 1171-1174.
[5] 王春波,王 丹,曹名卓,等. 温经活血外用药穴位贴敷治疗膝骨关节炎的疗效观察[J]. 中国中医急症, 2019, 28 (12): 2216-2219.
[6] Khella C M, Asgarian R, Horvath J M, et al. An evidence-based systematic review of human knee post-traumatic osteoarthritis (PTOA): timeline of clinical presentation and disease markers, comparison of knee joint ptoa models and early disease implications[J]. Int J Mol Sci, 2021, 22 (4): 1996.
[7] Marchand L S, Haller J M. Post-traumatic arthritis of the knee and ankle[J]. Orthop Clin North Am, 2024, 55 (4): 461-469.
[8] Lieberthal J, Sambamurthy N, Scanzello C R. Inflammation in joint injury and post-traumatic osteoarthritis[J]. Osteoarthritis Cartilage, 2015, 23 (11): 1825-1834.
[9] Yihan L, Yinshi R, Xin L, et al. Interleukin-6 signaling mediates cartilage degradation and pain in posttraumatic osteoarthritis in a sex-specific manner[J]. Sci Signal, 2022, 15 (744): eabn7082.
[10] 郑俊侨,张俏菊,吴欣颖,等. 穴位给药作用评价及应用情况研究进展[J]. 中国中药杂志, 2024, 49 (14): 3706-3713.
[11] 李旭豪,杨继国. 基于“药群”理论探讨传统中药穴位贴敷“四剂”药物组方思路及其临证应用[J]. 中华中医药杂志, 2023, 38:2163-2166.
[12] 段颖钰,李南臻,王孝艳,等. 李滋平用“上下膝五针”治疗膝骨关节炎经验[J]. 山东中医杂志, 2023, 42 (12): 1333-1337.
[13] 王 成,袁 君,郭彦玎,等. 艾灸“足三里”对膝关节骨关节炎与类风湿性关节炎大鼠膝关节滑膜巨 噬细胞极化的影响的比较研究[J]. 针刺研究, 2023, 48 (10): 993-1000.
[14] 刘 梨,周 巍,黎铭玉,等. 电针“足三里”“关元”穴对佐剂性关节炎大鼠滑膜细胞凋亡及相关凋亡蛋白表达的影响[J]. 针刺研究, 2022, 47 (8): 696-702.
[15] 李记泉,王 巍,戴俭宇,等. 曲池和血海穴对止痒效应的研究进展[J]. 中国医药导报, 2023, 20 (6): 51-54.
[16] 曾 进,张 丽,温小秋,等. 提插补泻血海穴对下肢胫前、胫后动脉血流变化的影响[J]. 针灸临床杂志, 2016, 32 (1): 38-40.
[17] 林月青,林映欣,方云添,等. 针刺血海穴强刺激治疗膝关节骨性关节炎临床观察[J]. 中医药通报, 2022, 21 (5): 50-52.
[18] Zhao H, Liu Y, Yang C, et al. Efficacy and safety of acupoint catgut embedding for knee osteoarthritis: a systematic review and meta-analysis[J]. Medicine, 2025, 104 (51): e46676.
[19] Zhao J, Liang G, Pan J, et al. Clinical efficacy of cortex daphnes (zushima) patch in patients with symptomatic knee osteoarthritis: a multicenter non-inferiority randomized controlled clinical trial[J]. Front Pharmacol, 2021, 12: 646310.
[20] Saadat P, Pereira T V, Lalji R, et al. Evidence-based hierarchy of pain outcome measures for osteoarthritis clinical trials and meta-analyses[J]. Osteoarthritis Cartilage, 2025, 33 (1): 42-49.
[21] 周 婧,吴家顺. 黄附姜贴敷治疗膝骨关节炎(寒湿证)的临床研究[J]. 湖北中医药大学学报, 2024, 26 (1): 87-89.
[22] 刘 倩,李海波,张 琪,等. 中西医结合外治法治疗早中期膝骨关节炎的疗效观察[J]. 中国中西医结合外科杂志, 2022, 28 (6): 790-794.
[23] Shtroblia V, Petakh P, Kamyshna I, et al. Recent advances in the management of knee osteoarthritis: a narrative review[J]. Front Med (Lausanne), 2025, 12: 1523027.
[24] Wang Z, Zheng X, Lin J, et al. Electroacupuncture ameliorates cartilage damage in a rat model of knee osteoarthritis and regulates expression of mirnas and the tlr4/nf-κb pathway[J]. Acupunct Med, 2025, 43 (3): 164-173.
[25] Wang S, Guan J, Gong W, et al. Transdermal delivery of traditional chinese medicine patch vs. Nsaids patch for alleviating inflammation and relieving pain for early-stage knee osteoarthritis: a retrospective case control study[J]. Front Pharmacol, 2025, 16: 1549883.
[26] Huang Y, Huang H, Chen Q, et al. Efficacy and immune-inflammatory mechanism of acupuncture-related therapy in animal models of knee osteoarthritis: a preclinical systematic review and network meta-analysis[J]. J Orthop Surg Res, 2024, 19 (1): 177.
[27] Cao Q, Li Y. Signal transduction pathways involved in acupuncture-mediated inhibition of synovitis in knee osteoarthritis: a comprehensive review[J]. Int J Gen Med, 2025, 18: 4105-4117.
[28] Ye J, Su C, Jiang Y, et al. Effects of acupuncture on cartilage p38mapk and mitochondrial pathways in animal model of knee osteoarthritis: a systematic evaluation and meta-analysis[J]. Front Neurosci, 2023, 16: 1098311.
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