Objective To assess the relationship between visceral pleural invasion (VPI) in T2 non-small cell lung cancer (NSCLC) and other clinicopathologic characteristics and to evaluate its significance as a prognostic factor. Methods 628 patients with T2 NSCLC underwent curative surgical resection in Miyun County Hospital and the First Hospital of Beijing University. The subjects included 265 patients with stage IB non-small cell lung cancer (T2N0M0) , 223 with stage IIB (T2N1M0), and 140 with stage ⅢA (T2N2M0). The patients were divided into two groups according to the VPI status (group Ⅰ without invation, group Ⅱ with invasion). Both groups were compared in tumor size, histology, associated lymph node involvement, and survival rates. Results VPI (group Ⅱ) was identified in 136 patients (21.7%) and was present in 70 patients with a tumor 3 cm or less and in 66 of patients with a tumor larger than 3 cm in size. 5- and 10-year survival rates were 53.7% and 40.0% in group Ⅰ, and 25.7% and 11.0% in group Ⅱ, respectively (P
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
［1］ Tyson L B. Non small cell lung cancer: new hope for a chronic illness［J］. Oncol Nurs Forum, 2007, 34(5):963-970.
［2］ Manach D, Riquet M, Medioni J, et al. Visceral pleural invasion by non-small cell lung cancer: an underrated bad prognostic factor［J］. Ann Thorac Surg, 2001，71: 1088-1093.
［3］ Shimizu K, Yishida J, Nagai K, et al. Visceral pleural invasion classification in non-small cell lung cancer: a proposal on the basis of outcome assessment［J］. J Thorac Cardiovasc Surg,2004,127: 1574-1578.
［4］ UICC TNM. classification of malignant tumors［M］. 6th ed. New Jersey: John＆Wiley, 2002:93-97.
［5］ Jeong H K, Kil D K, Kyung Y C. Prognostic value of visceral pleura invasion in non-small cell lung cancer［J］. Euro J Cardio-thorac Surg, 2003, 23: 865-869.
［6］ 裘国勤，陆小萍. 周围型非小细胞肺癌淋巴结隐匿转移的临床相关因素分析［J］.中华肿瘤防治杂志，2009，16(19)：1497-1500.
［7］ 苏晓东,龙 浩,王 欣,等.脏层胸膜受侵对IB期非小细胞肺癌预后的影响［J］.中华肿瘤杂志，2008,30(5):368-371.
［8］ Shim H S,Park I K,Lee C Y, et al.significance of visceral pleural invasion in the forthcoming (seventh) edition of TNM classification for lung cancer［J］. Lung Cancer, 2009，65：161-165.
［9］ Yilmaz A, Duyar S S, Cakir E, et al. Clinical impact of visceral pleural, lymphovascular and perineural invasion in completely resected non-small cell lung cancer［J］. Eur J Cardiothorac Surg, 2011，40(3):664-670.
［10］ 张国庆，王伯庆.非小细胞肺癌纵隔淋巴结转移规律及其廓清范围的探讨［J］.新疆医科大学学报，2007，30(6)：615-618.
［11］ Strauss G M, Herndom J E, Maddaus M A, et al. Adjuvant chemotherapy in stage I B non –small cell lung cancer (NSCLC): update of Cancer and Leukemia Group B(CALGB) protocol 9633 ［J］. J Clin Oncol,2006,24(18S):7007.
［12］ Chang Y L,Lin M W, Shih J Y, et al.The significance of visceral pleural surface invasion in 321 cases of non-small cell lung cancers with pleural retraction［J］.Ann Surg Oncol, 2012，19（9）：3057-3064.
PDF(640 KB)
