［1］ Dries D J. The contemporary role of blood products and components used in trauma resuscitation ［J］. Scand J Trauma Resusc Emerg Med, 2010, 18: 63

［2］ Brohi K, Cohen M J, Ganter M T, et al. Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway ? ［J］. Ann Surg, 2007, 245(5): 812-818.

［3］ MacLeod J B, Lynn M, McKenney M G, et al. Early coagulopathy predicts mortality in trauma［J］. J Trauma, 2003, 55(1): 39-44.

［4］ Kooistra T, Schrauwen Y, Arts J, et al. Regulation of endothelial cell t-PA synthesis and release［J］. Int J Hematol, 1994, 59(4): 233-255.

［5］ Kashuk J L, Moore E E, Sawyer M, et al. Primary fibrinolysis is integral in the pathogenesis of postinjury coagulopathy ［J］. Ann Surg, 2010, 251(3):434-444.

［6］ Kashuk J L, Moore E E, Sawyer M, et al. Postinjury coagulopathy management: goal directed resuscitation via POC thrombelastography ［J］. Ann Surg, 2010, 251(4): 604-614.

［7］ Jurkovich G J, Greiser W B, Luterman A, et al. Hypothermia in trauma victims: an ominous predictor of survival ［J］. J Trauma, 1987, 27(9): 1019-1024.

［8］ Valeri C R, Feingold H, Cassidy G, et al. Hypothermia-induced reversible platelet dysfunction［J］. Ann Surg, 1987, 205(2):175-181.

［9］ Yoshihara H, Yamamoto T, Mihara H. Changes in coagulation and fibrinolysis occurring in dogs during hypothermia［J］. Thromb Res, 1985, 37(4): 503-512.

［10］ Meng Z H, Wolberg A S, Monroe D M III, et al. The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients［J］. J Trauma, 2003, 55(5): 886-891.

［11］ Kashuk J L, Moore E E, Johnson J L, et al. Post injury life threatening coagulopathy: is 1:1 fresh frozen plasma:packed red blood cells the answer ［J］. J Trauma, 2008, 65(2):261-270.

［12］ Borgman M A, Spinella P C, Perkins J G, et al. The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital［J］. J Trauma, 2007, 63(4): 805-813.

［13］ Holcomb J B, Wade C E, Michalek J E, et al. Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients［J］. Ann Surg, 2008, 248(3):447-458.

［14］ Counts R B, Haisch C, Maxwell N G, et al. Hemostasis in massively transfused patients［J］. Ann Surg, 1979, 190(1): 91-99.

［15］ 刘景汉，汪德清．临床输血学［M］．北京：人民卫生出版社，2011：284-289．

［16］ 周 洁,吕 科,滕 方, 等. 血浆与红细胞不同输注比例对创伤性失血患者大量输血救治的影响［J］. 中国输血杂志, 2011, 24(10): 844-847.

［17］ 刘景兰．成分输血在急性创伤性骨折治疗中的应用［J］．中国创新医学, 2011, 8(31): 137-138.

［18］ Johnson J, Moore E E, Kashuk J, et al. Early transfusion of FFP is independently associated with post-injury MOF ［J］. Arch Surg, 2010, 145(10): 973-977.

［19］ Hoffman M, Monroe D III. A cell-based model of hemostasis ［J］. Thromb Haemost, 2001, 85(6): 958-965.