The detection of alpha-fetoprotein isoforms using with centrifugal column method in diagnosis of hepatocelluar carcinoma

DI  Xiao-Hui; ZHENG   Fei; XU   Juan; JIA  Zhi-Ling; LIU   Yang

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Medical Journal of the Chinese People Armed Police Forces ›› 2012, Vol. 23 ›› Issue (11) : 947-949.

The detection of alpha-fetoprotein isoforms using with centrifugal column method in diagnosis of hepatocelluar carcinoma

DI Xiaohui¹,ZHENG Fei²,XU Juan¹,JIA Zhiling³,and LIU Yang⁴

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Abstract

Objective To explore the clinical significance of alpha-fetoprotein-L3%( AFP-L3) with centrifugal column method in the diagnosis of hepatocelluar carcinoma. Methods The serum samples of 150 patients with elevated AFP level (≥20 ng/ml) were detected by chemiluminescence immunoassay for AFP and centrifugal column method for AFP-L3，and the clinical value of AFP-L3 were studied in the differentiation diagnosis of hepatocelluar cancer. Results Taking AFP-L3≥10 ng/ml as the diagnositic criteria，the sensitivity of AFP-L3 was 91.03% （71/78）in 78 hepatocellular carcinoma patients and the specificity of AFP-L3 was 95.83%(69/72）in 72 other liver diseases patients. The diagnostic accuracy was 93.33%［（71+69）/150］. Conclusion Detection of AFP-L3 seemed be of clinical value in benign or malignant liver disease.

Key words

alpha-fetoprotein isoforms / hepatocelluar / carcinoma / centrifugal column method

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DI Xiaohui,ZHENG Fei,XU Juan,JIA Zhiling,and LIU Yang. The detection of alpha-fetoprotein isoforms using with centrifugal column method in diagnosis of hepatocelluar carcinoma[J]. Medical Journal of the Chinese People Armed Police Forces. 2012, 23(11): 947-949

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