Objective To evaluate the efficacy of 64-slice CT coronary angiography for treating coronary intermediate lesion. Methods 120 patients whose coronary stenosis degree ranged from 50% to 70% (intermediate lesion) with CT values of lesion plaque being (18±26) HU and fat volumes larger than 40% determined by the 64-slice CT examination，were enrolled and randomly assigned into interventional therapy group(60 cases) and pharmacotherapy group (60 cases), and the treatment effects of coronary intermediate lesion between interventional therapy group and pharmacotherapy group were compared and the results of follow-up 10 to 12 months after the surgery were analyzed. Results Forty-six patients in interventional group underwent the 64-slice CT examination during 10 to 12 months after the surgery，and the results were as follows: no patient with thrombus symptoms in local stent, 2 patients with stent restenosis (the loss of the inner diameter of stent at late period larger than 50%) and 5 patients with stent intimal hyperplasia (different degrees of luminal stenosis). Forty-five patients underwent 64-slice CT examination during 10 to 12 months after discharge in pharmacotherapy group. Among them，6 patients were found to be with luminal stenosis aggravated to 85% with significant difference as compared with that of prior to the treatment; no obvious changes were found in the 29 patients with luminal stenosis; 10 patients were found with lumen size slightly enlarged; 25 patients were found with CT value of plaque increased to (70±12) HU. Of the 60 patients in the pharmacotherapy group，10 patients underwent coronary stenting due to the aggravating angina，and 3 patients underwent coronary stenting due to acute myocardial infarction. Conclusions 64 slice CT for determining CT value of plaque is a helpful means in determining the necessity of intervention.