Objective To analyze the characteristics of bone metastasis in prostate cancer of Uygur and Han people in Urumqi region in Xinjiang. Methods Bone scanning with SPECT was performed in 25 Uygur patients with prostate cancer (PCa) and 41 Han patients with PCa. Serum osteocalcin was detected by radioimmunoassay. Serum total prostate-specific antigen (T-PSA), free prostate specific antigen (F-PSA), and the ratio (F/T) were detected by chemiluminescence immunoassay. Results The positive rate of bone scintigraphy was 52.0%（13 cases）in Uygur PCa patients and 75.6% (31cases) in Han PCa patients, and the difference was statistically significant(P<0.05). The level of serum osteocalcin in Han PCa patients was significantly higher than that in the Uygur PCa patients (P<0.05). As to the level of F-PSA and T-PSA, there was not statistically significant difference between Uygur and Han PCa patients (P>0.05). However, the ratio of F/T in Han PCa patients was significantly lower than that in the Uygur PCa patients (P<0.05). Conclusions There might be difference in bone metastasis in PCa between Uygur and Han people in Urumqi region in Xinjiang that clinicians should pay attention to.