Objective To compare the efficacy and safety of dezocine and sufentanil in patient controlled intravenous analgesia following resection of colon cancer. MethodsSixty patients scheduled for resection of colon cancer, aged 42 to 70, ASAⅠ～Ⅱ, were randomly arranged into dezocine group(group D) and sufentanil group (group S)of 30 patients each. All the patients were given general anesthesia and treated with patient controlled intravenous analgesia (PCIA) towards the end of operation. PCIA gradients used for group D and group S were decozine 0.8 mg/kg and sufentanil 2 μg/kg, respectively, which were diluted to 100 ml by adding saline. VAS, Ramsay scores(3 h, 6 h, 12 h, 24 h, 48 h after operation), pressing times of PCA equipment and adverse effects were recorded and compared. ResultsThere was no significant difference in the VAS scores and pressing times of PCA equipment (P>0.05) . The Ramsay scores and adverse effects in group D were significantly lower than those in group S (P<0.05). ConclusionsDezocine in PCIA following resection of  colon cancer exhibits good effect of analgesia and minor adverse reactions, which can serve as a safe and more effective method of analgesia.