Levels of bloodplasma Lp-PLA-2 in patients with acute cerebral infarction complicated by metabolic syndrome

Medical Journal of the Chinese People Armed Police Forces ›› 2012, Vol. 23 ›› Issue (5) : 378-380.

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PDF(484 KB)
Medical Journal of the Chinese People Armed Police Forces ›› 2012, Vol. 23 ›› Issue (5) : 378-380.

Levels of bloodplasma Lp-PLA-2 in patients with acute cerebral infarction complicated by metabolic syndrome

  • ZHU Lixun1, GENG Ruihui2, LU Xuesheng1, and DING Suju3.
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Abstract

Objective  To investigate the level of blood plasma Lp-PLA-2 in patients with acute cerebral infarction complicated by metabolic syndrome(MS) and to investigate the correlation between LP-PLA and MS.  Methods  We studied 74 hospitalized patients with acute cerebral infarction. They were divided into MS group and non-MS group according to the criteria of MS published by International Diabetes Federation (IDF). The level of blood plasma Lp-PLA-2 and blood serum TC, TG, LDL-C, HDL-C was detected by ELISA.  Results  Significant difference was observed between patients with acute cerebral infarction complicated by MS in levels of plasma Lp-PLA-2 and non-MS group (38.87±5.44 vs 36.44±4.15,  P =0.037). The level of serum triglyceride(TG) was also higher ( P <0.05).  Conclusions  MS induces elevation of the level of plasma Lp-PLA-2.

Key words

lipoprotein- associated phospholipase A-2 / metabolic syndrome / acute cerebral infarction

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Levels of bloodplasma Lp-PLA-2 in patients with acute cerebral infarction complicated by metabolic syndrome[J]. Medical Journal of the Chinese People Armed Police Forces. 2012, 23(5): 378-380

References

[1]DavisB,KosterG,DouetLJ,etal.Electrosprayionizationmassspectrometryidentifiessubstratesandproductsoflipoprotein-associatedphospholipaseA2inoxidizedhumanlowdensitylipoprotein[J].JBiolChem,2008,283(10):6428-6437.

[2]GrundySM,CleemanJI,MerzCN,etal.ImplicationofrecentclinicaltrialsforthenationalcholesteroleducationprogramadulttreatmentpanelIIIguidelines[J].Circulation,2004,110(6):227-239.

[3]AlbertiKG,ZimmetP.Themetabolicsyndrome-anewworldwidedefinition[J].Lancet,2005,366(9491):1059-1062.

[4]SchaloskeRH,DennisEA.ThephospholipaseA2surperfamilyanditsgroupnumberingsystem[J].BiochimBiophysActa,2006,1761(11):1246-1259.

[5]TjoelkerLW,EberhardtC,UngerJ,etal.Plasmaplatelet-activatingfactoracetylhydrolaseisasecretedphospholipaseawithacatalytictriad[J].JBiolChem,1995,270(43):25481-25487.

[6]TselepisAD,DentanC,KarabinaSA,etal.PAF-degradingacetylhydrolaseispreferentiallyassociatedwithdenseLDLandVHDL-1inhumanplasma.Catalyticcharacteristicsandrelationtothemonocyte-derivedenzyme[J].ArteriosclerThrombVascBiol,1995,15(10):1764-1773.

[7]ZalewskiA,MacpheeC.Roleoflipoprotein-associatedphospholipaseA2inatherosclerosis:biology,epidemiology,andpossibletherapeutictarget[J].ArteriosclerThrombVascBiol,2005,25(5):923-931.

[8]BlakeGJ,DadaN,FoxJC,etal.Aprospectiveevaluationoflipoproteinassociated-phospholipaseA(2)levelsandtheriskoffuturecardiovasculareventsinwomen[J].JAmCollCardiol,2001,38(5):1302-1306.

[9]BrilakisES,KheraA,McGuireDK,etal.Influenceofraceandsexonlipoprotein-associatedphospholipaseA2levels:observationsfromtheDallasHeartStudy[J].Atherosclerosis,2008,199(1):110-115.

[10]KimJA,YehDC,VerM,etal.PhosphorylationofSer24inthepleckstrinhomologydomainofinsulinreceptorsubstrate1byMousePelle-likekinase/interleukin-1receptor-associatedkinase:cross-talkbetweeninflammatorysignalingandinsulinsignalingthatmaycontributetoinsulinresistance[J].JBiolChem,2005,280(24):23173-23183.

[11]〖JP4〗BuseMG.Hexosamines,insulinresistance,andthecomplicationsofdiabetes:currentstatus[J].AmJPhysiolEndocrinolMetab,2006,290(1):E1-E8.

[12]LowellBB,ShulmanGI.Mitochondrialdysfunctionandtype2diabetes[J].Science,2005,307(5708):384-387.

[13]RuanH,HacohenN,GolubTR,etal.Tumornecrosisfactoralphasuppressesadipocyte-specificgenesandactivatesexpressionofpreadipocytegenesin3T3-L1adipocytes:nuclearfactor-kappaBactivationbyTNF-alphaisobligatory[J].Diabetes,2002,51:1319-1336.

[14]迟家敏.实用血脂学[M].北京:人民卫生出版社,2010:221-222.

[15]HajerGR,vanderGraafY,OlijhoekJK,etal.Lowplasmalevelsofadiponectinareassociatedwithlowriskforfuturecardiovasculareventsinpatientswithclinicalevidentvasculardisease[J].AmHeartJ,2007,154(4):750.e1-7.

[16]SuganamiT,Tanimoto-KoyamaK,NishidaJ,etal.RoleoftheToll-likereceptor4/NF-kappaBpathwayinsaturatedfattyacid-inducedinflammatorychangesintheinteractionbetweenadipocytesandmacrophages[J].ArteriosclerThrombVascBiol,2007,27(1):84-91.

[17]Lp-PLA(2)StudiesCollaboration,ThompsonA,GaoP,etal.Lipoprotein-associatedphospholipaseA(2)andriskofcoronarydisease,stroke,andmortality:collaborativeanalysisof32prospectivestudies[J].Lancet,2010,375(9725):1536-1544.
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