Clinical analysis of candidal pneumonia in liver failure patients

SUN lijian; LIN Fang; SU Haibin; LI Lei; ZHAO Hong; and WANG Huifen

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Medical Journal of the Chinese People Armed Police Forces ›› 2012, Vol. 23 ›› Issue (5) : 403-406.

SUN lijian^1,2, LIN Fang²，SU Haibin²，LI Lei², ZHAO Hong²，and WANG Huifen².

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Abstract

Objective To investigate the clinical features and risk factors of candidal pneumonia in liver failure patients. Methods 150 hospitalized patients with candidal pneumonia from January 1986 to December 2007were analysed retrospectively. Results Broad-spectrum antibiotics were used in 90.0% of the patients and corticosteroids 47. 3% of the patients. 73% of the patients had only lung fungal infection. The main species of Candida was Candida albicans (66%) and Candida tropicalis (16%). Fever (70%) cough and expectoration(85.3%) were the most common clinical features. Leucocytosis was found in 50% of the patients and neutrophil increased in 46.7%. Better effect was achieved when the anti-fungal therapy was initiated earlier or along with long-term therapy regimen (≥2 weeks). Conclusions Most Candidal pneumonia patients with liver failure are given broad-spectrum antibiotics. Candida albicans is popularly used. Fever, cough and expectoration are the most common clinical features. Better outcomes come with early use and sufficient duration of antibiotics.

Key words

candida / pneumonia / liver failure

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SUN lijian, LIN Fang，SU Haibin，LI Lei, ZHAO Hong，and WANG Huifen. Clinical analysis of candidal pneumonia in liver failure patients[J]. Medical Journal of the Chinese People Armed Police Forces. 2012, 23(5): 403-406

References

［1］ Rajiv Jalan. Acute liver failure:current management and future prospects［J］. J Hepatol, 2005, 42 suppl(1):S115-123.

［2］中华医学会感染病学分会肝衰竭与人工肝学组、中华医学会肝病学分会重型肝病与人工肝学组. 肝衰竭诊疗指南［J］. 中华肝脏病杂志，2006, 14（9）：643-646.

［3］黄晓军.血液病/恶性肿瘤患者侵袭性真菌感染的诊断标准与治疗原则［J］.中华内科杂志, 2010,49(5): 451-454.

［4］中华医学会传染病与寄生虫学分会、肝病学分会联合修订. 病毒性肝炎防治方案［J］. 中华内科杂志, 2001, 40(1): 62-68.

［5］Gustot T, Durand F, Lebrec D,et al . Severe sepsis in cirrhosis［J］. Hepatology, 2009, 50(6):2022-2023.

［6］Galbois A, Thabut D, Tazi K A,et al . Ex vivo effects of high-density lipoprotein exposure on the lipopolysaccharide induced inflammatory responses in patients with severe cirrhosis［J］. Hepatology, 2009, 49（1）：175-184.

［7］侯周华，谭德明，刘国珍,等. 慢性重型肝炎患者侵袭性真菌感染的临床特点及治疗分析［J］.中南大学学报，2010, 35(6):537-542.

［8］林芳，王慧芬，苏海滨,等. 肝衰竭合并念珠菌肺炎病原菌谱及危险因素分析［J］. 解放军医学杂志，2009, 34（2）：215-218.

［9］李新成.重型肝炎合并真菌感染60例临床分析［J］. 现代中西医结合杂志, 2002, 11(17):1679-1680.

［10］陈更瑞,方华盛. 肺部真菌感染CT 诊断［J］.中华实用诊断与治疗杂志，2010，24（5）：473-474.

［11］王慧芬,张战红,张伟, 等. 重型病毒性肝炎真菌感染37例分析［J］. 中华医院感染学杂志， 2000, 10（1）：31-31.

［12］ Dean D A, Burchard K W. Surgical perspective on invasive candida infections［J］. World J Surg, 1998, 22(2):127-134.

［13］袁云峰，曾繁荣，马厚勋，等. 氟康唑治疗258例老年肺部念珠菌感染疗效分析［J］ . 中国现代医学杂志，2005, 15（9）：1352-1354.