Clinicopathological features of primary hepatic sarcoma

SUN Lu; SHI Huaiyin; WEI Lixin

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Medical Journal of the Chinese People Armed Police Forces ›› 2012, Vol. 23 ›› Issue (5) : 427-430.

SUN Lu, SHI Huaiyin，and WEI Lixin.

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Abstract

Objective To investigate the clinicopathological features and differential diagnosis of primary hepatic angiosarcoma (PHA). Methods Eleven cases of PHA were investigated at the light microscopic level and were studied by immunohistochemical techniques. Results Macroscopically, tumors showed diffuse, multi-nodular or single nodular patterns. Heamorrhage were observed. Microscopically, the tumor composed of endothelial cells which formed the irregular vessels or cavernous vascular space. Tumor cells were spindle-shaped or epithelioid with atypical nuclei. Multinucleated cells and prominent mitosis were seen in some areas. Immunohistochemical staining showed expression of Vimentin，CD31 and CD34 in all cases. Some cases had F-VⅢ associated antigen expression. None of the cases had Desmin, CD117, AFP or CK expression. Conclusions PHA is a rare malignant heamangioendothelial tumor. Its histological and immohistochemical features are necessary for the confirmation of diagnosis.

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liver / angiosarcoma / pathology

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SUN Lu, SHI Huaiyin，WEI Lixin. Clinicopathological features of primary hepatic sarcoma[J]. Medical Journal of the Chinese People Armed Police Forces. 2012, 23(5): 427-430

References

［1］ Molina E, Hernandez A. Clinical manifestations of primary hepatic angiosarcoma ［J］. Dig Dis Sci, 2003, 48(4): 677–682.

［2］ Bolt H M. Vinyl chloride - a classical industrial toxicant of new interest ［J］. Crit Rev Toxicol, 2005, 35(4): 307–323.

［3］ Kim H R, Rha S Y, Cheon S H, et al . Clinical features and treatment outcomes of advanced stage primary hepatic angiosarcoma ［J］. Annals Oncology, 2009, 20(4): 780–787.

［4］ Yin D Z, Zheng Q C, Yuan Y N. Hepatic angiosarcoma: an analysis of 7 cases ［J］. Chinese-German J Clin Oncol, 2011, 10(8): 484-486.

［5］ Weitz J, Klimstra D S, Cymes K, et al . Management of primary liver sarcomas ［J］. Cancer, 2007, 109(7): 1391–1396.

［6］丛文铭，朱世能. 肝胆肿瘤诊断外科病理学［M］.上海：科技教育出版社. 2002：186-188.

［7］〖JP3〗Li Q, Hao X S. Hepatic angiosarcoma: a review of twelve cases［J］. Chin J Clin Oncol, 2005, 2(1): 457-461.

［8］ Hanno M, Andreas K, Moritz S, et al . Long-term survival after surgery for primary hepatic sarcoma in adults ［J］. Arch Surg, 2009, 144(4): 339-344.

［9］ Trojan J, Hammerstingl R, Engels K, et al . Contrast-enhanced ultrasound in the diagnosis of malignant mesenchymal liver tumors［J］. J Clin Ultrasound, 2010, 38(5): 227-231.

［10］ Park Y S, Kim J H, Kim K W, et al . Primary hepatic angiosarcoma: imaging findings and palliative treatment with transcatheter arterial chemoembolization or embolization［J］. Clin Radiol, 2009, 64(8): 779-785.

［11］李小秋, 黄海林, 王东海. 甲胎蛋白对原发性肝癌及肝硬化诊断价值研究［J］. 武警医学, 2009, 20(8): 716-717.

［12］〖JP3〗Timaran C H, Grandas O H, Bell J L. Hepatic angiosarcoma: long-term survival after complete surgical removal［J］. Am Surg, 2000, 66(12): 1153–1157.

［13］ Arima-Iwasa S, Chijiiwa K, Makino I, et al . A case of hepatic angiosarcoma surviving for more than 16 months after hepatic resection［J］. Hepatogastroenterology, 2007, 54(7): 533–535.