Objective To study the safety and effectiveness of nitrous oxide (≤70%) for colonoscopy. Methods A total of 630 patients who underwent colonoscopy from April 2011 to December 2011 were divided into group A (nitrous oxide-colonoscopy group, n =330) and group B (conventional colonoscopy group, n =300). Their heart rate (HR), oxygen saturation and sedative effects were compared. Results The perioperative reaction in group A was obviously lower than in group B. In group A, the perioperative HR was obviously lower than the preoperative HR ［（74.90±13.65） vs (79.16±14.67)， P ＜0.05］ and the perioperative SpO2 was significantly higher than the preoperative SpO2 ［（99.64±1.04）% vs (99.14± 1.35)%， P ＜0.05］. In group B, the perioperative HR was significantly higher than the preoperative HR （89.80±13.52） vs (79.77±13.35)， P ＜0.05］ and the perioperative SpO2 was slightly higher than the preoperative SpO2 ［（99.64±1.04）% vs （99.14±1.35）%， P ＜0.05］，but the difference was not statistically significant. Conclusions Nitrous oxide for colonoscopy is comfortable, safe and feasible.
Key words
nitrous oxide /
conscious sedation /
lower gastrointestinal tract /
colonoscopy /
evaluation
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