Objective To evaluate the liquid-based cytology in the diagnosis of thyroid diseases. Methods Two hundred cases of thyroid lesion in outpatient and inpatient departments underwent liquid-based cytological examinations to compare the quality and diagnosis of traditional manual smear preparation. Results The preserved specimens and smears made with liquid-PREP showed an increased number of valuable cells, a cleaner background, uniform distribution, less thyroid colloid in the smear and clear nuclei. The positive rate of thyroid cancer was 6.55% (15/229) in liquid-PREP and 3.93% (9/229) in traditional manual smear preparation. Conclusions Liquid-PREP improves the smear quality and positive rate of cancer in thyroid fine needle aspiration cytology and can serve as a promising diagnostic method for thyroid lesion.
Key words
thyroid diseases /
thyroid cancer /
liquid-based cytology /
fine needle aspiration cytology
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
［1］ Ko H M, Jhu I K, Yang S H, et al . Clinicopathologic analysis of fine needle aspiration cytology of the thyroid. A review of 1,613 cases and correlation with histopathologic diagnoses ［J］. Acta Cytol, 2003, 47(5): 727-732.
［2］ Rossi E D, Rafaeli M, Minimo C, et al . Immunohistochemical evaluation of thyroid neoplasms in Thin-Layer smears from fine needle aspiration biopsie ［J］.Cancer Cytopathology, 2005,105(2): 87-95.
［3］ Das D K, Sharma P N. Diagnosis of papillary thyroid carcinoma in fine needle aspiration smears: factors that affect decision making ［J］. Acta Cytologica, 2009, 53(5): 497-506.
［4］ 高鹏霞，陆卫平，刘影，等. 细针甲状腺穿刺活检在甲状腺疾病诊断中的价值［J］. 江苏医药杂志，2011，37(18)：2140-2141.
［5］ Yeung M J, Serpell J W. Management of the solitary thyroid nodule ［J］. Oncologist, 2008,13(2): 105-112.
［6］ 林毅，吴艺捷.甲状腺细针穿刺细胞学检查对甲状腺结节的诊断价值.使用预防学［J］. 2009, 16（5）：1549-1550.
［7］ 周斌，左新华，左淑英，等. 液基细胞学技术在甲状腺细胞学诊断的应用价值探讨［J］. 实验与检验医学杂志，2011，29（1）：27-29.
［8］ 张智慧，潘秦镜，孙耘田. 针吸液基薄片与传统涂片的对比研究［J］. 中华肿瘤杂志，2004，26(2)：102-105.
［9］ Lee T I, Yang H J, Lin S Y, et al . The accuracy of fine-needle aspiration biopsy and frozen section in patients with thyroid cancer ［J］. Thyroid, 2002,12(7):619-626.
［10］林毅，吴艺捷. 甲状腺细针穿刺细胞学检查对甲状腺结节的诊断价值［J］.实用预防医学，2009，16(5)：1549-1550.
［11］赵洋，廖子龙，郑爱萍. 甲状腺结节的组织病理学与细胞学对比研究［J］. 河北医学杂志，2011，17(8)：997-999.
［12］余小蒙，周小鸽，黄受方. 针吸标本采集技术的发展及应用价值［J］. 诊断病理学杂志，2008，15（4）：264.
PDF(724 KB)
