Objective To investigate the effect of Alprostadil Injection combined with hyperbric oxygen in treatment of acute severe carbon monoxide.Methods 110 patients with acute severe carbon monoxide were randomly divided into control group and treatment group. All the cases received the hyperbaric oxygen therapy based on the internal comprehensive treatment. Then, treatment group was treated with Alprostadil Injection 10 μg/d，which lasted 14 days.Results The total effective rate was 92.8% in treatment group, much higher than in the control group (P＜0. 05). The rate of fatality and delayed encephalopathy after acute carbon monoxide poisoning and cerebral infarction was significantly reduced in the control group,but there was no statistical significance.Conclusion Alprostadil Injection combined with hyperbric oxygen for treating acute severe carbon monoxide can facilitate the recovery of functions while reducing delayed encephalopathy after acute carbon monoxide poisoning and cerebral infarction.
Key words
acute severe carbon monoxide /
alprostadil injection /
hyperbric oxygen therapy
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