Objective To examine the expression & correlation of estrogen receptors, progesterone receptors in uterine sarcoma. Methods Immunohistochemistry was used to examine the expression of estrogen receptors & progesterone receptors in uterine sarcoma. Their correlation was analyzed. Results There was significant difference in the positive rate of ERα protein between endometrial stromal sarcoma tissues, uterine leiomyosarcoma tissues and uterine carcinosarcoma tissues(P <0.01) on one hand and normal myometrium tissues on the other hand. The PRA、 PRB positive rate of endometrial stromal sarcoma tissues was considerably different ( P <0.05) from that of uterine leiomyosarcoma tissues and uterine carcinosarcoma tissues. Conclusion ERα, ERβ and PRA, PRB were all expressed in endometrial stromal sarcoma tissues, uterine leiomyosarcoma tissues, uterine carcinosarcoma tissues, and normal myometrium tissues. The expression of ERα is positively correlated with PRA and PRB in endometrial stromal sarcoma tissues.
Key words
estrogen receptor α /
estrogen receptor β /
progesterone receptor A /
progesterone receptor B /
immunohistochemistry /
uterine sarcoma
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
［1］ Amant F，Coosemans A，Debiec-Rychter M,et al.Clinical management of uterine sarcomas［J］.Lancet Oncol，2009，10(12):1188-1198.
［2］ 陈 罡,侯巧燕,陈 峰，等.免疫组织化学染色SP法操作程序的规范和改良［J］.医学文选,2004,23(4):419-421.
［3］ Amant F，Dreyer L，Makin J．Uterine sarcomas in south African black women:a clincopathologic study with ethnic considerations［J］.Eur J Gynaecol Oncol, 2001，22(3):194-200.
［4］ Albrektsen G,Heuch I,Wik E,et al.Prognostic impact of parity in 493 uterine sarcoma patients［J］.Int J Gynecol Cancer,2009 19(6)：1062-1067.
［5］ 刘晓霞，翟曜耀，赵 越.雌激素受体ERa的功能调控及相关性疾病的研究进展［J］.中国细胞生物学学报,2011,1(1):65-71.
［6］ Huang G S,Arend R C,Li M,et al.Tissue microarray analysis of hormonal signaling pathways in uterine carcinosarcoma［J］.Am J Obstet Gynecol,2009,200(4):457.
［7］ 王海霞.ERα、ERβ、PRA、PRB、pS2在子宫肉瘤中的表达研究［D］.青岛：青岛大学,2005.
［8］ 庄育红. ER、PR受体及亚型表达与子宫内膜异常病变的相关性研究［D］.南京：东南大学,2009.
PDF(3639 KB)
