Objective To observe the efficacy and safety of using mifepristone combined with misoprostol and ethacridine respectively in induced termination of pregnancy during the second and third trimester. Methods 120 women undergoing legal induced abortion during the second and third trimester were divided randomly into two groups. Group A with 60 patients were given oral mifepristone and misoprostol sequentially while 60 patients in group B were given mifepristone orally and ethacridine by amniotic injection. The rate of success and surgical evacuation, induction-abortion interval, blood loss, side effects and complications were observed. Results Both methods achieved good results, without significant difference in terms of bleeding or safety. The former, without amniotic administration, had a lower surgical evacuation rate than the latter (P
Key words
second trimester pregnancy /
induced abortion /
mifepristone /
misoprostol /
ethacridine
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