Objective To study the right ventricular systolic function after interventional closure of patent ductus arteriosus in Tibetan children by two-dimensional strain imaging technique. Methods The sample consisted of thirty-one PDA children in the Tibetan region. The TEE was in stable condition one day before and seven days after closure. The other twenty children were recruited as control group. More than three continuous cardiac cycles were taken and induced into Echo PAC before the curve of systole peak strain was obtained. Results The strain of the septal and right ventricular wall was lower than that in control group before closure. There was no difference in septal segments between Tibetan and control group after closure, but the strain in the Tibetan group was still lower than that in control group in the right ventricular wall after closure（P<0.01）. The strain of the basal and middle ventricular septal and basal and middle right ventricular wall increased（P<0.01），as in the right ventricular wall（P<0.05）. Apical ventricular septal strain increased but the difference was not statistically significant. Conclusions Myocardial systolic function of the right ventricular wall cannot be restored quickly after closure, so a long period of follow-up is required. Two-dimensional technique can quantitatively evaluate the myocardial contraction in PDA patients and is more sensitive than the value of EF.
Key words
strain /
patent ductus arteriosus /
myocardial systole /
Tibetan region
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References
［1］ 杨 杰，王一彪. 小儿心脏病学理论与实践［M］. 北京：人民军医出版社，2009:130-132.
［2］ Thébaud B, Michelakis E D, Wu X C, et al. Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus ［J］. Circulation, 2004, 110(11): 1372-1379.
［3］ Chen Z Y, Wu L M, Luo Y K, et al. Comparison of long-term clinical outcome between transcatheter Amplatzer occlusion and surgical closure of isolated patent ductus arteriosus［J］. Chin Med J (Engl), 2009, 122(10): 1123-1127.
［4］ Kim R W, Ugurlu B S, Tereb D A, et al. Effect of left ventricular volume on results of coronary artery bypass grafting ［J］. Am J Cardiol, 2000, 86 (11):1261-1264.
［5］ Martinez D A, Guhl D J, Stanley W C, et al. Extracellular matrix maturation in the left ventricle of normal and diabetic swine ［J］. Diabetes Res Clin Pract, 2003, 59(1):1-9.
［6］ 雍永宏，庄 燕，姚 静，等. 二维斑点追踪技术评价房间隔缺损封堵术前后右室应变及应变率变化［J］. 南京医科大学学报，2009，29(8): 1128-1132.
［7］ 高 含，谢明星，方凌云，等. 超声斑点追踪成像技术评价动脉导管未闭患者右心室收缩功能 ［J］. 中华临床医师杂志，2011，15(5): 6558-6561.
［8］ Geyer H, Caracciolo G, Abe H, et al. Assessment of myocardial mechanics using speckle tracking echocardiography:fundamentals and clinical applications ［J］. J Am Soc Echocardiogr, 2010, 23(4): 351-369.
［9］ 张富生. 高原与低氧性肺动脉高压［J］. 中国工业医学杂志，2002，15(8): 108-110.
［10］ 周贵明，黄灿亮，万 征，等. 超声二维应变技术评价肺动脉高压患者右室收缩功能［J］. 中国慢性病预防与控制，2010，18(4): 403-405.
［11］ 郭炜华，史旭波，王国宏，等. 巨大动脉导管未闭合并肺动脉高压患者介入封堵的可行性和有效性研究 ［J］. 临床荟萃，2011，5(26): 1473-1475.
［12］ Lindqvist P, Calcutteea A, Henein M, et al. Echocardiography in the assessment of right heart function ［J］. Eur J Echocardiogr, 2008, 9(2): 225-234.
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