Objective To investigate the expression of c-myc and cyclinE in endometrial polyps, and to clarify the pathogenesis of endometrial polyps in molecular level. Methods 64 patients with premenopausal endometrial polyps were recruited as polyps group. At the same time, from the same 64 patients’ endometium, far from endometrial polyps, normal endomentrial tissues were taken as control group 1. And, from other 64 premenopausa patients, who underwent hysteroscopic removal of contraceptive ring or hysteroscopic resection of uterine septum, normal endometrial tissues were taken as control group 2. Immunohistochemistrical Methods were used to detect c-myc、cyclinE expression and to compare in each group of glands and stroma. Results The positive rates of expression of c-myc in glands and stroma in polyps group were 76.6% and 71.9%, respectively. And the positive rates of expression of cyclinE in glands and stroma were 81.3% and 75.0%, respectively. These rates were higher than those in the control groups and the difference was statistically significant（P＜0.01）. The expression of c-myc and cyclinE in glands and stroma in endometrial polyps was positively correlated（r=0.585，P＜0.01；r=0.522，P＜0.01）. Conclusions Excessive expression of c - myc and cyclinE in premenopausal endometrial polyps of the glands and stroma may be the cause of occurrence and development of endometrial polyps.
Key words
Endometrial polyps /
c-myc /
cyclinE
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