Objective To study the effect of integrated candesartan cilexetil tablets and acteoside capsules on microalbuminuria in patients with early diabetic nephropathy. Methods Fifty-six patients with early diabetic nephropathy were recruited and randomly divided into two groups, the single group and the integrated group. In the single group, 28 cases were treated with candesartan cilexetil tablets (4 mg穚o穛d );in the integrated group,28 cases were treated with integrated candesartan cilexetil tablets(4 mg穚o穊id) and acteoside capsules (0.4 g穚o穊id). BP(blood pressure), FBG(fasting blood glucose),2hFBG(2-hour postprandial blood glucose), Bun,Scr, SCys-C and UMA were examined before and after treatment.Results There was no statistically significant difference between the two groups before treatment. After treatment, Cys-C and UMA were lower than that before treatment in both groups (P<0.01), and were remarkably reduced in the integrated group contrasted with the single group (P<0.01). Conclusions Integrated candesartan cilexetil tablets and acteoside capsules have no remarkable influence in BP, BG, Bun and Scr, but efficiently decrease the SCys-C and UMA in patients with early diabetic nephropathy.So the onset of clinical proteinuria can be delayed and the renal function can be protected.