Objective To study serum soluble intercellular adhesion molecule ( sICAM-1), soluble vascular cell adhesion molecule ( sVCAM-1), soluble E-select the element ( sE-selectin) changes in 28 patients surviving more than 48 hours after cardiopulmonary resuscitation ( CPR). Methods By using the method of randomized controlled studies after cardiopulmonary resuscitation ( CPR) , noninfectious factors of sudden cardiac arrest patients survived more than 48 hours in 28 cases, using the double antibody enzyme-linked immunosorbent method to determine recovery before each period after recovery, the serum average change levels of sICAM-1, sVCAM-1, sE-selectin were compared with the time change difference. Results Before 12 hours after recovery, serum sVCAM-1 sICAM-1 and sE-selectin levels showed a trend of gradually increasing over time, and in the recovery after 24 hours except sICAM-1, sE-selectin continued to rise, sVCAM-1 significantly reduced, 48 hours after recovery, sICAM-1 sVCAM-1 also slowed or significantly reduced, and sE-selectin significantly. Conclusions Serum sVCAM-1, sICAM-1 and sE-selectin levels in each period after recovery remain high and rising although spontaneous circulation after certain perfusion is verified, and vascular endothelial injury is still not terminated, tissue and organ functions further fail.
Key words
post-resuscitation /
sICAM-1 /
sVCAM-1 /
sE-selectin
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References
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