Objective To discuss the clinical implications of urinary β₂ microglobulin(U-β₂-MG)and its related factors in T2 Diabetes Mellitus patients with diabetic nephropathy(DN).　Methods We collected 171 diagnosed DN patients (male 109, female 62). Correlation analysis of U-β₂-MG and the other clinical test items was made. Correlation analysis was made again after we divided patients into three groups: simple DM , DM with hypertension, DM with hypertension and hyperlipidemia. Results Positive correlation between levels of U-β₂-MG and indices as A₁β, IgG, a1-MG, level of SCr and SBP was found. Within group DM, levels of U-β₂-MG had an significantly positive correlation with levels of CHO、HDL、BUN, while showing negative correlation with GFR. In the group of DM with hypertension, there was a positive correlation with levels of U-β₂-MG and those of SBP,CHO,LDL,SCr, and a negative correlation with GFR . In the last group, there was an significantly positive correlation between levels of U-β₂-MG and DBP,LDL,BUN,and still a negative correlation with level of U-β₂-MG and GFR.　Conclusions Damage of Tubule interstitial is easily found in DN patients. U-β₂-MG was negatively correlated with GFR, indicating that U-β₂-MG has already increased when GFR slightly decreased. The produce of U-β₂-MG is closely related to the level of blood glucose ,blood pressure, and lipid level. U-β₂-MG was significantly associated with CHO, LDL-C, SCr, which showed that early active control of blood lipid might have positive effects on the prognosis of DN, especially in aspect of avoiding renal tubular damage.