Objective To study the effects of smoking and smoking cessation on arterial hardness in healthy subjects. Methods Seventy-five chronic smoking healthy subjects were divided into maintaining smoking group (n=26) and ex-smoking group (n=21).Another 28 no-smoking healthy subjects were used as control group. The arterial hardness reflected by baPWV(brachial-ankle pulse wave velocity) was compared at baseline and after 1 month or 6 months of smoking cessation. Results The maintaining smoking group and ex-smoking group had higher values of baPWV than no-smoking group at baseline(P<0.05). After 1 month of smoking cessation, there was no difference in baPWV between maintaining smoking group and ex-smoking group(P>0.05), the same as between pre- and post-smoking cessation(P>0.05). After 6 month of smoking cessation, there was a decline in baPWV in ex-smoking group, when compared with maintaining smoking group(P<0.05). The same decrease was also observed between pre- and post-smoking cessation(P<0.05). Conclusions Smoking is associated with a decline of the arterial compliance, and 1 month of smoking cessation does not improve the arterial elasticity. But 6 months of smoking cessation improves the arterial elasticity.
Key words
smoking /
smoking cessation /
brachial-ankle pulse wave velocity /
arterial hardness
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] Cao X, Xiao H, Zhang Y, et al. 1, 5-Dicaffeoylquinic acid-mediated glutathione synthesis through activation of Nrf2 protects against OGD/reperfusion-induced oxidative stress in astrocytes[J]. Brain Res, 2010,1347:142-148.
[2] Kim J W, Park C G, Hong S J, et al. Acute and chronic effects of cigarette smoking on arterial stiffness[J]. Blood pressure, 2005,14(2):80-85.
[3] Kubozono T, Miyata M, Ueyama K, et al. Acute and chronic effects of smoking on arterial stiffness[J]. Circulation journal : official journal of the Japanese Circulation Society, 2011,75(3):698-702.
[4] O’Rourke M F, Hashimoto J. Mechanical factors in arterial aging: a clinical perspective[J]. Journal of the American College of Cardiology, 2007,50(1):1-13.
[5] Willum-Hansen T, Staessen J A, Torp-Pedersen C, et al. Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population[J]. Circulation,2006,113(5):664-670.
[6] 茶春喜,罗 仁,杜晓强, 等. 踝臂脉搏波传导速度对冠状动脉病变的预测价值[J]. 临床和实验医学杂志, 2011,10(10):774-775.
[7] Jatoi N A, Jerrard-Dunne P, Feely J, et al. Impact of smoking and smoking cessation on arterial stiffness and aortic wave reflection in hypertension[J]. Hypertension,2007,49(5):981-985.
[8] Polonia J, Barbosa L, Silva J A, et al. Improvement of aortic reflection wave responses 6 months after stopping smoking: a prospective study[J]. Blood pressure monitoring,2009,14(2):69-75.
