Objective To study the central metabolic characteristics and the change in central metabolism in patients with tinnitus undergoing masking therapy. Methods Select Five subjects with normal hearing tinnitus and, at the same time, twenty normal people who have undergone PET-CT examination were recruited. The tinnitus patients’ standardized uptake values(SUV) of right and left transverse temporal gyri and hippocampal gyrus were compared with those in normal subjects. SUV of 5 tinnitus patients were compared on each side of transverse temporal gyri and hippocampal gyrus before masking therapy with those having masking therapy. Results Of 5 cases of tinnitus, transverse temporal gyri and hippocampal gyrus metabolism was asymmetric in 4 cases, and the left metabolism was significantly higher than the right side on all performance. The other one was normal. All metabolism in normal control group was symmetrical. Between the two groups, the asymmetric indexes were significantly different (P＜0.01). And in 5 cases of tinnitus with masking therapy, SUV of auditory cortex with sound in one side masking therapy was higher than that without sound, each side before masking therapy and after had significant difference (P< 0.01). Conclusions The high metabolism of the left transverse temporal gyri and hippocampal gyrus is associated with tinnitus. Masking therapy has curative efficacy and may affect the metabolic level of auditory cortex functional area.
Key words
tinnitus /
positron—emission tomography /
auditory cortex
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