Objective To evaluate the effect of pre-hospital fluid resuscitation on patients with traumatic hemorrhagic shock. Methods 76 patients identified by severe closed trauma combined with uncontrolled hemorrhagic shock were divided into two groups. The patients were pair matched 38 patients each ,dependent on the difference in pre-hospital fluid resuscitation input volume, that is, restrictive fluid resuscitation and routine fluid resuscitation. The general clinical symptoms, treatment, organ failure in hospital, incidence and mortality rate of infection before and after admission were compared. Results Pre-hospital comparison of the two groups: infusion volume decreased sharply in the group of restrictive fluid resuscitation, [(789.6±109.4)ml vs (2381.9±403.5) ml,P＜0.01],resuscitation time shortened obviously　[(59.3±15.5)min vs (80.1±17.4)min,P＜0.01].Laboratory tests and treatment in hospital: hemoglobin increased sharply in group of restrictive fluid resuscitation [(101.0±12.9) g/L vs (92.1±11.8)g/L,P＜0.01],coagulation function improved [(78.8±8.2)% vs(63.1±12.6)%,P<0.01],blood products input reduced, [CRBC:(6.4±2.1)U vs(7.5±4.6)U,P＜0.01;frozen plasma(5.1±3.0)U vs(6.4±2.0)U,P＜0.01].Organ failure in group of restrictive fluid resuscitation (21.0% vs 39.4%,P<0.01), infection incidence rate(13.1% vs 26.5%,P<0.01)and other complications decreased. Conclusions Maintaining moderate fluid resuscitation pre-hospital improves coagulation function and oxygen supply, and decreases organ failure including infection incidence rate.