Objective To study the value of coronary CTA imaging in interventional therapy of chronic coronary artery occlusion(CTO) lesions. Methods The clinical data of 62 patients with CTO were analyzed retrospectively, 32 cases with preoperative CT examination as group A; 30 patients without CTA check as group B. Vascular recanalization rates, guide wire non-passaging rates, and incidence rates of complications in the two groups were compared. Results Blood vessel recanalization rate in group A was 73.17%, and that in group B was 42.11%, with significant difference between the two groups (P<0.05). The an average time of operation in group A with vascular recanalization was (75?30) min; that in group B was (105?40) min, with significant difference (P<0.05). The average density of CT in CTO lesions of group A with successful interventional treatment was (400?72) Hu, whereas that in those with failing intervention treatment was (520?108) Hu, with significant difference (P<0.01). Conclusions CTO lesions mean CT density, vascular occlusion time, and vascular lesion length influence the success rate of interventional therapy; CT examination improves the success rate of interventional therapy CTO lesions and reduces time of interventional therapy.