Detection of serum D-dimer and CRP in patients with colorectal cancer and its clinical significance

LIU Qinghua; XU Fangcheng; BAO Caiqin; LI Yongfen; and MA Jia

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Medical Journal of the Chinese People Armed Police Forces ›› 2014, Vol. 25 ›› Issue (11) : 1089-1091.

ORIGINAL ARTICLES

Detection of serum D-dimer and CRP in patients with colorectal cancer and its clinical significance

LIU Qinghua¹, XU Fangcheng², BAO Caiqin¹, LI Yongfen², and MA Jia¹

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Abstract

Objective To evaluate the clinical significance of serum D-dimer and C-reactive protein (CRP) detection in patients with colorectal carcinoma. Methods Fifty-three patients and thirty healthy controls were enrolled and bloods were sampled from controls at examination and patients pre-operation and on days 1, 3, 7 post-operation respectively. Serum D-dimer and CRP were detected. The results were analyzed considering the pathologic parameters such as TNM staging, lymph nodes metastasis and vascular invasion. Contrastive analyses were performed between the measurements of laparoscopic and open resection cases. Results D-dimer and CRP levels in patients were significantly higher than in controls(P＜0.01). D-dimer and CRP levels in patients with lymph nodes metastasis or vascular invasion were significantly higher than in negative cases. Serum D-dimer and CRP were increased by the TNM stages promotion. Serum D-dimer and CRP were both increased post-operation and then decreased. D-dimer was attenuated to normal level and CRP was still significantly higher than pre-operation at 7 days post-operation. CRP in patients undergoing laparoscopic resection were significantly lower than in those undergoing open resection. Pre-operative CRP and D-dimer were positively correlated(r=0.432,P＜0.05). Conclusions Serum D-dimer and CRP are correlated with pathologic degrees in CRC; combined measurements of these two indexes may be significant in early diagnosis, prognosis and post-operative inflammation judgment in CRC.

Key words

C-reactive protein / D-dimer / colorectal carcinoma

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LIU Qinghua, XU Fangcheng, BAO Caiqin, LI Yongfen, and MA Jia. Detection of serum D-dimer and CRP in patients with colorectal cancer and its clinical significance[J]. Medical Journal of the Chinese People Armed Police Forces. 2014, 25(11): 1089-1091

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