Expression of Ki67,EGFR in triple negative breast cancer and correlation analysis

ZHANG Miao; REN Li; HU Rong; CHU Xiaoyu; and ZHU Guangqing

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Medical Journal of the Chinese People Armed Police Forces ›› 2014, Vol. 25 ›› Issue (12) : 1256-1258.

ORIGINAL ARTICLES

Expression of Ki67,EGFR in triple negative breast cancer and correlation analysis

ZHANG Miao,REN Li, HU Rong,CHU Xiaoyu,and ZHU Guangqing

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Abstract

Objective To study Ki67, EGFR in non-triple negative and triple negative expression in breast cancer, and to explore the correlation between Ki67 and EGFR gene expression. Methods Immune histochemical method was used to detect Ki67 in specimens of 513 cases of breast cancer and the expression of EGFR, comparing both in triple negative and none triple negative breast cancer, and the correlation was analyzed by chi square and Spearman method. Results Ki67 positive expression rate in triple negative breast cancer tissues (94.32%) was significantly higher than that in triple negative breast cancer (80.47%) (P<0.05). Triple negative rate of EGFR expression in breast cancer tissue (68.18%) was significantly higher than that of non-triple negative breast cancer (11.76%) (P<0.05). Conclusions Ki67 and EGFR expression in triple negative breast cancer increases,but no correlation between both,has important significance in breast cancer prognosis judgement.

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triple negative breast cancer / Ki67 / EGFR

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ZHANG Miao,REN Li, HU Rong,CHU Xiaoyu,and ZHU Guangqing. Expression of Ki67,EGFR in triple negative breast cancer and correlation analysis[J]. Medical Journal of the Chinese People Armed Police Forces. 2014, 25(12): 1256-1258

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