Objective To studythe feasibility of the transradial approach for coronary angiography using PTCA guidewire through the radioulnar loop. Methods From January to December in 2012,a total of 2600 patients undergoing transradial coronary angiography were recruited.Retrogarde radial arteriography was performed when hydrophilic wire could not cross the radial artery, if we found radioulnar loop ,we randomized the patients into two groups,one group try to cross the radioulnar loop with PTCA guidewire,another group revert to transfemoral approach. Patient demographics,procedure duration, amount of contrast media usage, and dose area product(DAP) were recorded. Results radioulnar loops were noted in 52 patients(2 %),the success rate was notsignificantly different, procedue duration was longer in PTCA guidewire group, DAP was higher in PTCA guidewire group, the amount of contrast media usage and vascular complication rate was not significant. Conclusions Although radioulnar loop prolongs the procedure duration and increases DAP, the success rate is nonsignifican.