Objective To study the efficacy and safety of continuous veno-venous hemofiltration(CVVH) therapy on the crush injury dog by using portable continuous blood purification machine(PCBPM) in the simulated seismic environment. Methods Eight healthy adult male dogs were crushed by animal extrusion equipment model and developed crush syndrome(CS) related acute kidney injury(AKI). The injured dogs were treated with PCBPM on the seismic simulation platform, the control of fluid replacement volume and dehydration accuracy of PCBPM were calculated, and breathing rate, heart rate, mean arterial pressure, anal temperature, serum creatinine, blood urea nitrogen, and electrolytes were measured. Results (1)The mean control of fluid replacement volume accuracy was 2.60%; the mean dehydration accuracy was 0.27%, the machine worked normally during the experiment. (2)Crushed by the weight 8 h, dogs developed crush syndrome and acute kidney injury,and after the treatment,the main physiological and biochemical indicators improved significantly (P<0.05), all dogs survived successfully. Conclusions Dogs suffering from CS related AKI can be cured safely and effectively by PCBPM in the simulated seismic environment.
Key words
portable continuous blood purification machine /
simulated seismic environment /
crush injury /
crush syndrome /
acute kidney injury
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References
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