Objective To study the influencing factors of the hypertensive cerebral hemorrhage complicated with massive cerebral infarction patients. Methods Retrospective analysis was conducted of 165 cases of hypertensive cerebral hemorrhage, and the possible factors that might cause cerebral infarction were summed up. Single factor analysis and multiple factors analysis were done to analyze the relationship between these factors and massive cerebral infarction after hypertensive cerebral hemorrhage. Multiple factors analysis was conducted using Logistic regression analysis, α=0.05. Results Logistic stepwise regression analysis screened out such factors as the shift extent of brain (OR=2.439,95% CI 1.371-4.303), the volume of edema (OR=1.502,95% CI 1.166-31.935), the size of hematoma (OR=1.438,95% CI 1.068-1.908), the history of hypertension (OR=1.026,95% CI 1.032-1.110), diastolic pressure(1.019,95% CI 1.011-1.028) and systolic pressure(OR=1.017,95% CI 1.008-1.026) that would influence the massive cerebral infarction after hypertensive cerebral hemorrhage. The correlation degree was not high with the age, plasma osmotic pressure and blood sugar. Conclusions The hypertensive cerebral hemorrhage complicated by massive cerebral infarctin is the interactive effect of the multiple factors. The shift extent of brain, the extent of edema, the size of hematoma, the extent of edema, the history of hypertension and the degree of diastolic pressure and systolic pressure are all the influence factors.