Objective To evaluate the diagnostic value of capsule endoscopy (CE) for small intestine diseases. Methods The clinical data of 196 patients who underwent CE were retrospectively analyzed. Grouped according to different symptoms, the positive rate of small intestinal diseases was analyzed by χ² test in groups. Results Small bowel examinations for 195 patients were completed. The inspection success rate was 86.6% (169/195). The diagnostic positive rate 80.8% (68/84) in digestive bleeding group was higher than in the other groups (P＜0.01). The diagnostic positive rate in diarrhea group was 64.7% (11/17), in abdominal pain group was 50.82% (30/59), in weight reduction group was 50% (2/4) and in abdominal distension group was 38.4% (5/13). Conclusions OMOM capsule endoscopy has good security and compliance, it can be used in finding small intestine disease, especially in patients with obscure gastrointestinal bleeding.