Objective To evaluate the analgesic effect and side effects of flurbiproten on patients receiving open abdominal surgery. Methods Forty patients receiving open abdominal surgeries were randomized to different regimens of PCA. Study group PCA: 60 mg morphine +200 mg flurbiproten/240 ml; control group PCA:60 mg morphine/240 ml. Background infusion rate:4 ml/h, bolus 4ml;lock time:15 mins. The VAS、drug doses consumption and side effects were evaluated. Results There were no differences between the VAS and side effects,except the drug consumption at 4 hours after the operation; there were no differences between drug consumptions on the other time points. Conclusions Compared with the PCA with only morphine, PCA plus flurbiproten can not increase the analgesic effect, nor the morphine consumption.