Clinical effect of valsartan / amlodipine combination therapy in treatment of essential hypertension

ZHOU  Bin-Wei; YUAN  Yi; BI  Ying; WANG  Fei; DUAN  Jia-Jia; LIU  Xin-Lin; ZHAO  Ji-Hong

PDF(577 KB)

Medical Journal of the Chinese People Armed Police Forces ›› 2014, Vol. 25 ›› Issue (8) : 774-776.

ORIGINAL ARTICLES

Clinical effect of valsartan / amlodipine combination therapy in treatment of essential hypertension

ZHOU Binwei,YUAN Yi,BI Ying,WANG Fei,DUAN Jiajia,LIU Xinlin,ZHAO Jihong

Author information +

History +

Abstract

Objective To investigate the clinical efficacy of valsartan / amlodipine combination and different time of taking medicine in treatment of essential hypertension. Methods 201 essential hypertensive subjects (92 men/109 women), were recruited randomized to receive valsartan(80 mg/day) and amlodipine (5 mg/day) in one of the following four therapeutic schemes: both medications on awakening, both at bedtime, either one administered on awakening and the other at bedtime. BP was measured by ambulatory monitoring for 24 consecutive hours before and after 12 wks of treatment. Results BP-lowering efficacy (quantified in terms of reduction of the 24-h mean of systolic/diastolic BP) was highest when both antihypertensive medicines were ingested at bedtime, as compared with any one of the three other tested therapeutic schemes[A(123.0±13.2)mmHg/(73.1±6.7)mmHg、B(113.6±11.0)mmHg/(67.1±8.3)mmHg、C(124.4±13.7)mmHg/(73.6±9.0)mmHg、D(119.8±13.0)mmHg/(70.6±7.2)mmHg,P<0.01]. Conclusions The greater proportion of controlled patients, improved efficacy on lowering asleep BP mean, and increased sleep-time relative BP decline suggest that valsartan/amlodipine combination therapy should be preferably administered at bedtime.

Key words

valsartan / amlodipine / essential hypertension / combination therapy

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

ZHOU Binwei,YUAN Yi,BI Ying,WANG Fei,DUAN Jiajia,LIU Xinlin,ZHAO Jihong. Clinical effect of valsartan / amlodipine combination therapy in treatment of essential hypertension[J]. Medical Journal of the Chinese People Armed Police Forces. 2014, 25(8): 774-776

References

[1] Chobanian A V,Bakris G L,Black H R,et al. Seventh report of the Joint National Committee on prevention,detection,evaluation,and treatment of high blood pressure[J]. Hypertens, 2003,42:1206-1252.
[2] Mancia G,De Backer G,Dominiczak A,et al.2007 guidelines for the management of arterial hypertension. The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)[J]. Hypertension, 2007,25:1105-1187.
[3] 唐哲,孙玉坤,李耀红,等. 氨氯地平对比索洛尔在大鼠体内药动学的影响[J]. 武警医学,2013,24(4):319-322.
[4] 贾德安,王志坚,杨士伟,等.缬沙坦/氨氯地平或氨氯地平单药治疗高危高血压患者[J].中华高血压杂志,2013,21(6):569-572.
[5] Allemann Y,Fraile B,Lambert M,et al. Efficacy of the combination of amlodipine and valsartan in patients with hypertension uncontrolled with previous monotherapy:the Exforge in Failure after Single Therapy (EX-FAST) study[J]. Clin Hypertens,2008,10:185-194.
[6] Brachmann J, Ansari A,Mahla G,et al. Effective and safe reduction of blood pressure with the combination of amlodipine 5 mg and valsartan 160 mg in hypertensive patients not controlled by calcium channel blocker monotherapy[J].Adv Ther,2008,25:399-411.
[7] Liebson P R. Calcium channel blockers in the spectrum of antihypertensive agents[J]. Expert Opin Pharmacother,2003,7:2385-2401.
[8] Miura S,Saku K.Efficacy and safety of angiotensin Ⅱ type 1 receptor blocker/calcium channel blocker combination therapy for hypertension:focus on a single-pill fixed-dose combination of valsartan and amlodipine [J].J Int Med Res ,2012,40(1):1-9.
[9] Flack J M,Calhoun D A,Satlin L,et al. Efficacy and safety of initial combination therapy with amlodipine/valsartan compared with amlodipine monotherapy in black patients with stage 2 hypertension:the EX-STAND study[J].Hum Hypertens,2009,23:479-489.
[10] Philipp T,Smith T R,Glazer R,et al. Two multicenter,8-week,randomized, double-blind,placebo-controlled,parallel-group studies evaluating the efficacy and tolerability of amlodipine and valsartan in combination and as monotherapy in adult patients with mild to moderate essential hypertension[J].Clin Ther,2007,29:563-580.
[11] Schunkert H,Glazer R D,Wernsing M,et al. Efficacy and tolerability of amlodipine/valsartan combination therapy in hypertensive patients not adequately controlled on amlodipine monotherapy[J].Curr Med Res Opin,2009,25:2655-2662.
[12] Sinkiewicz W,Glazer R D,Kavoliuniene A,et al. Efficacy and tolerability of amlodipine/valsartan combination therapy in hypertensive patients not adequately controlled on valsartan monotherapy[J].Curr Med Res Opin,2009,25:315-324.
[13] Koopman M G,Koomen G C,Krediet R T,et al. Circadian rhythm of glomerular filtration rate in normal individuals[J].Clin Sci (Lond),1989,77:105-111.
[14] Labrecque G,Beauchamp D.Rhythms and pharmacokinetics.In Redfern P (ed.).Chronotherapeutics.London:Pharmaceutical Press,2003:75-110.
[15] Boggia J, Li Y,Thijs L,et al. Prognostic accuracy of day versus night ambulatory blood pressure: a cohort study[J].Lancet,2007,370:1219-1229.
[16] Brotman D J,Davidson M B,Boumitri M,et al. Impaired diurnal blood pressure variation and all-cause mortality[J]. Hypertens,2008,21:92-97.
[17] Benetos A,Safar M,Rudnichi A,et al. Pulse pressure:a predictor of long-term cardiovascular mortality in a French male population.[J].Hypertension,1997,30:1410-1415.
[18] Verdecchia P,Schillaci G,Reboldi G,et al. Different prognostic impact of 24-hour mean blood pressure and pulse pressure on stroke and coronary artery disease in essential hypertension[J].Circulation,2001,103:2579-2584.