Association of serum chemerin levels with type 2 diabetes mellitus accompanied by coronary artery disease

LAN  Li-Juan; LI  Hong-Tao; WANG  Xiao-Dong; YAO  Min; YANG  Tao; LI  Cheng-Liang; LIU  Wei

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Medical Journal of the Chinese People Armed Police Forces ›› 2014, Vol. 25 ›› Issue (8) : 777-779.

ORIGINAL ARTICLES

Association of serum chemerin levels with type 2 diabetes mellitus accompanied by coronary artery disease

LAN Lijuan,LI Hongtao,WANG Xiaodong,YAO Min,YANG Tao,LI Chengliang,LIU Wei

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Abstract

Objective Chemerin is a newly discovered adipokine. This aim of the study was to determine the association of serum chemerin levels with the development of type 2 diabetes mellitus accompanied by coronary artery disease. Methods This study consisted of 256 patients with type 2 diabetes mellitus: 156 without coronary artery disease and 100 with coronary artery disease. Serum chemerin levels were investigated in the two groups by enzyme-linked immunosorbent assay. Multivariable logistic regression analysis was used to analyze the correlation between type 2 diabetes mellitus and the coronary artery disease. Results Type 2 diabetes mellitus patients with combined coronary artery disease showed significantly elevated serum chemerin levels compared with those without coronary artery disease. Serum chemerin level was a determinant parameter of the presence of coronary artery disease in type 2 diabetes mellitus patients. Conclusions Serum chemerin level can serve as a predictive serum marker for the development of coronary artery disease in type 2 diabetes mellitus patients.

Key words

serum / chemerin / diabetes mellitus, type 2 / coronary artery disease / inflammation

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LAN Lijuan,LI Hongtao,WANG Xiaodong,YAO Min,YANG Tao,LI Chengliang,LIU Wei. Association of serum chemerin levels with type 2 diabetes mellitus accompanied by coronary artery disease[J]. Medical Journal of the Chinese People Armed Police Forces. 2014, 25(8): 777-779

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