Objective To investigate the roles of soluble vascular cell adhesion molecule-l(sVCAM-1), pregnancy associated plasmaprotein A(PAPP-A) and interleukin-6(IL-6) in pregnancy-induced hypertension. Methods Ninety-two pregnant woman diagnosed as having pregnancy-induced hypertension were recruited and divided into gestational hypertension group(50 cases), preeclampsia group(30 cases)and eclampsia group(12 cases). Eighty healthy pregnant women were set as controls. sVCAM-1、PAPP-A were measured by chemiluminescence and IL-6 was measured by radioimmunoassay. Results The levels of sVCAM-1, PAPP-A and IL-6 in preeclampsia group and eclampsia group were significantly higher than those in control group(P<0.01). The levels of sVCAM-1 and PAPP-A had significant correlation in groups of preeclampsia and eclampsia(r=0.85, P<0.05), and the levels of IL-6 and sVCAM-1 had positive correlation in groups of preeclampsia and eclampsia(r=0.64, P<0.05).Conclusions SVCAM 1, PAPP - A and IL - 6 have obvious ralationship with gestational hypertension. They can be applied in the clinical generalization, increase the rate of early diagnosis and treatment of eclampsia and reduce maternal and perinatal mortality.
Key words
hypertension /
soluble vascular cell adhesion molecule-l /
pregnancy associated plasmaprotein A /
interleukin-6
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