Objective To investigate the effect of atorvastatin on plasma MMP-9 and IL-18 in patients with acute coronary syndrome (ACS). Methods Sixty patients with ACS were randomly divided into treatment group (taking atorvastatin 20 mg/d for 14 days), control group (no atorvastatin, other treatments were similar to treatment group). Before drug therapy and after 14 days, MMP-9 and IL-18 levels in serum were measured. Results Compared with pre-treatment, the levels of MMP-9 and IL-18 in treatment group were decreased [(295±110)mg/L vs(358±95)mg/L;(399±115)pg/ml vs(471±105)pg/ml ,respectively],these differences were statistically significant (P<0.05). Moreover, the levels of MMP-9 and IL-18 in treatment group were significantly lower than those in control group [(358±95)mg/L,(466±109)pg/ml, respectively], these differences were statistically significant (P<0.05). Conclusions Atorvastatin can decrease serum MMP-9 and IL-18 levels in patients with ACS, which contributes to inhibit plaque inflammation, to advance the stability of plaque. Early intensive atorvastatin treatment may yield more significant benefits to the patients with ACS.
Key words
acute coronary syndrome /
atorvastatin /
matrix metalloproteinase-9 /
interleukin-18
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