Efficacy of Ⅰb and Ⅱ stage cervical cancer treated by intensity-modulated radiotherapy after surgery

YANG Jian; XU Xinming; LIU Ying; and XU Gang

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Medical Journal of the Chinese People Armed Police Forces ›› 2015, Vol. 26 ›› Issue (10) : 1001-1003.

ORIGINAL ARTICLES

Efficacy of Ⅰb and Ⅱ stage cervical cancer treated by intensity-modulated radiotherapy after surgery

YANG Jian¹,XU Xinming¹, LIU Ying¹,and XU Gang²

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Abstract

Objective To analyze the efficacy and treatment related toxicities for patients with Ⅰb and Ⅱ stage cervical cancer treated by Intensity Modulated Radiation Therapy (IMRT).Methods From January 2008 to February 2012,83 patients with stageⅠb-Ⅱ postoperative cervical cancer were retrospectively analyzed.The clinical target volume received a dose of 50 Gy/25 fractions in all patients.All patients were treated by IMRT and cisplatin-based chemotherapy for 2-4 cycles.Results Treatment was completed successfully in all patients. The follow-up rate was 100%. In all patients, the 3-year overall survival (OS) rate was 89.2％, with disease-free survival (DFS) rate of 83.1％ and pelevic local control (LC) rate of 85.5％. The 3-year OS rates were 50％ and 91％ for patients with adenocarcinoma and squamous carcinoma(χ²=9.65,P=0.002). The incidences of grade 1-2 rectal toxicity , urinary toxicity and myelosuppression were 10.34％,10.34％ and 58.62％. There were no grade 4 toxicities.Conclusions The postoperative cervical cancer patients with poor prognostic factors who undergo IMRT can achieve high overall survival rates,local control rates and tolerable toxicities.

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cervical neoplasms/radiochemotherapy / intensity modulated radiation therapy / prognosis

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YANG Jian,XU Xinming, LIU Ying,and XU Gang. Efficacy of Ⅰb and Ⅱ stage cervical cancer treated by intensity-modulated radiotherapy after surgery[J]. Medical Journal of the Chinese People Armed Police Forces. 2015, 26(10): 1001-1003

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