Objective To study the improving effect of non-invasive ventilation on ventilation condition and clinical symptoms in patients with respiratory failure caused by severe pneumonia. Methods 50 patients with respiratory failure caused by severe pneumonia in this hospital were randomly divided into study group and control group. Study group received noninvasive positive pressure ventilation, whereas control group received nasal oxygen catheterization. Then, ventilation condition, cardiac function index, serum inflammatory mediators amd adverse reactions were compared between the two groups. Results Ventilation index: in the study group PaO2(82.32±9.34)mmHg, SaO2(95.52±9.19)% was significantly higher than in the control group, (70.29±7.78)mmHg, SaO2(90.01±9.04)%; PaCO2 was significantly lower than in the control group(t=2.150-6.161, P<0.05). Cardiac function index: in the study group RR, HR, LVEDD were significantly lower than in the control group, LVEF was significantly higher than in the control group(t=3.284-5.022, P<0.05). Inflammation medium content: in the study group, TNF-α, IL-6, IL-1β were significantly lower than in the control group(t=11.928-19.9444, P<0.05). Adverse reactions: in the study group adverse reactions rate was 40.00%, significantly lower than 68.00% in the control group. Conclusions Noninvasive positive pressure ventilation improves ventilation condition and clinical symptoms, and relieves inflammation.
Key words
severe pneumonia /
respiratory failure /
noninvasive positive pressure ventilation /
inflammatory mediators
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