Objective To study the diagnostic value of serum heart-type fatty-acid binding protein(H-FABP)for non-ST-elevation acute coronary syndromes(NSTE ACS). Methods H-FABP and cTnI were measured and compared in 115 NSTE ACS patients and 69 non-cardiac chest pain patients. Results The H-FABP levels were (459±312) pg/ml, (237±169) pg/ml in NSTE ACS group and non-cardiac chest pain group respectively, and there was a significant difference between the two groups(P＜0.05).In NSTE ACS group, the H-FABP level of UAP group was (340±285) pg/ml which was lower than NSTE AMI group (592±289) pg/ml, and there was a significant difference between the two groups(P＜0.05). For the diagnosed NSTE AMI, the area under the ROC curve of H-FABP was 0.863, the sensitivity was 97.1%, specificity was 47.6%; while for the cTnI were 0.799, 61.2%, 93.9%.Conclusions H-FABP is a highly sensitivie marker of the early NSTE ACS and H-FABP detection is conducive to diagnosis of NSTE ACS.
Key words
non-ST-elevation acute coronary syndrome /
heart-type fatty-acid binding protein
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