Objective To study the expression and clinical significance of glioma-associated oncogene homolog 1 (Gli1) and matrix metalloproteinases-9 (MMP-9) in estrogen-independent breast cancer. Methods The expression of Gli1 protein was examined by Envision immunohistochemistry, Gli1, MMP-9 and CD34 expression were examined in ER-negative breast cancer. The relationships between them and CD34, tumor size, TNM stages, lymph node metastasis, HER-2 expression in ER-negative breast cancer were analyzed. Results The expression of CD34 was enhanced by the expression of Gli1 and MMP-9 in ER-negative group(CD34 expression were 48.83±7.53,60.69±10.02,64.68±12.92,75.91±11.30 in different group of Gli1;CD34 expressions were 48.15±8.44,61.69±10.71,67.76±14.03,73.11±12.78 in different group of MMP-9), with significant differences (P<0.05). The expression of Gli1 and MMP-9 were correlated with tumor size and clinical TNM stages in ER-negative breast cancer (P<0.05). The expression of MMP-9 was also correlated with lymphatic metastasis (P<0.05). The correlation existed between the expression of Gli1 and MMP-9 in ER-negative breast cancer(r=0.462, P<0.01). Conclusions Clinical positive correlation exists between the expression of Gli1 and MMP-9, Gli1 is an important regulating point in estrogen-independent breast cancer growth way.
Key words
breast cancer /
estrogen receptor /
immunohistochemistry /
Gli1 /
matrix metalloproteinases-9
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