Objective To study the relationship between HBV Pre-S1 antigen,HBV Pre-S2 antigen and HBV-DNA and investigate the clinical significance of the hepatitis B virus (HBV). Methods The markers Pre-S1 antigen, Pre-S2 antigen were determined by ELISA and HBV-DNA by the fluorescence quantitative PCR in 420 patients with HBV collected from September 2013 to May 2014. HBV, Pre-S1 antigen and Pre-S2 antigen results were analysed in different aspects, such as serum indices, HBV-DNA amounts and HBV-DNA infection types. Results In “big sanyang” patients the positive rates of Pre-S1, S2 antigen and HBV-DNA were 98.48%, 95.45%, 100%,respectively.In “small Sanyang” patients, the positive rates of Pre-S1, S2 antigen and HBV-DNA were 53.25%, 45.45%, 46.75%,respectively.In HBsAg+ HBcAb+ patients the positive rate of Pre-S1, S2 antigen and HBV-DNA were 53.75%, 43.28%, 44.78%,respectively.And the detection rates of HBV Pre-S1 antigen, HBV Pre-S2 antigen were higher in patients infected with high level of HBV-DNA. Conclusions There is a good correlation between HBV Pre-S1 antigen, HBV Pre-S2 antigen and HBV-DNA, which can reflect virus infection and replication.
Key words
Pre-S1Ag /
Pre-S2Ag /
HBV-DNA
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