Carotid intima-media thickness is associated with mean platelet volume, platelet volume distribution width and hypersensitive c-reactive protein in patients without clinical manifestation of atherosclerotic cardiovascular disease

SHI Genlin; YAO Liyun; LIU Hua; ZHU Feng

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Medical Journal of the Chinese People Armed Police Forces ›› 2015, Vol. 26 ›› Issue (7) : 673-676.

Carotid intima-media thickness is associated with mean platelet volume, platelet volume distribution width and hypersensitive c-reactive protein in patients without clinical manifestation of atherosclerotic cardiovascular disease

SHI Genlin¹, YAO Liyun², LIU Hua³, ZHU Feng⁴

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Abstract

Objective To study the relationship between carotid intima-media thickness (IMT) and mean platelet volume (MPV), platelet volume distribution width (PDW) and hypersensitive c-reactive protein (Hs-CRP) without clinical manifestation of atherosclerotic cardiovascular disease. Methods Retrospective analysis was performed. We studied the individuals who underwent the color Doppler ultrasound from February to November in 2014. The patients who had known atherosclerotic disease were excluded from study and 85 cases were finally admitted for the study. The patients were divided into IMT high group (55 cases) and IMT normal group (30 cases) according to the median carotid IMT values. A multiple linear regression analysis was performed to identify the independent associations of carotid IMT. Results The IMT high group had higher triglycerides (TG), uric acid (UA), MPV, PDW and Hs-CRP levels than those of the IMT normal group (P<0.05 for all). Multiple linear regression analysis showed that carotid IMT was independently related with MPV (β＝0.215, P<0.001), PDW(β＝-0.039, P=0.037)and Hs-CRP (β=0.258, P=0.001). Conclusions MPV、PDW or Hs-CRP is independently related to the extent of subclinical carotid atherosclerosis respectively. Increase in MPV may be a crucial biochemical marker for initial atherosclerosis.

Key words

carotid intima-media thickness / mean platelet volume / platelet volume distribution width / hypersensitive C-reactive protein / atherosclerotic disease

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SHI Genlin, YAO Liyun, LIU Hua, ZHU Feng. Carotid intima-media thickness is associated with mean platelet volume, platelet volume distribution width and hypersensitive c-reactive protein in patients without clinical manifestation of atherosclerotic cardiovascular disease[J]. Medical Journal of the Chinese People Armed Police Forces. 2015, 26(7): 673-676

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