Clinical effect and safety of artesunate in treatment of advanced retinoblastoma

ZHANG Yuanyuan; MIAO Lixia; SUN Yanfeng; WANG Jun; LI Yanshan; LIU Hongyan; YUAN Hailian; ZHANG Xianglan; YANG Xinji; LIU Qiuling

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Medical Journal of the Chinese People Armed Police Forces ›› 2015, Vol. 26 ›› Issue (7) : 712-715.

ORIGINAL ARTICLES

Clinical effect and safety of artesunate in treatment of advanced retinoblastoma

ZHANG Yuanyuan¹, MIAO Lixia², SUN Yanfeng², WANG Jun², LI Yanshan², LIU Hongyan², YUAN Hailian², ZHANG Xianglan²,YANG Xinji³, LIU Qiuling^1,2

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Abstract

Objective To study the clinical effect and safety of artesunate combined with conventional therapeutic schedule for children with advanced retinoblastoma. Methods We summarized clinical data of 11 cases who were treated with artesunate combined with conventional therapeutiy with advanced retinoblastoma as combination group between Octobor 1 2012 to January 31 2014 in the General Hospital of Chinese People’s Armed Police Forces. At the same time, 11 cases of advanced retinoblastoma with single conventional therapeutic schedule were selected as control group. The efficacy and safety were reviewed. Results (1)There were two of four(2/4,50%) cases of successfully reserved eyeball in children with intraocular D-E stage, and two cases in five(2/5,40%) received surgery opportunity with extraocular stage in combination group; two cases(2/7,28.6%) of successful reserved eyeball with intraocular D-E stage in seven patients, and one case(1/3,33.3%) received surgey opportunity with extraocular stage in three children in control group. (2)By the end of February 1,2015, the median progression-free survival and the median overall survival were 18.2 months and 21.8 months respectively in the combination group, which compared with control group(the median progression-free survival was 18.4 months and the median overall survival was 21 months), the difference was not statistically significant. (3)All patients did not show allergic reactions during the artesunate therapy and vital signs were stable. No significant difference was found in toxicity between the the two groups (P>0.05). Cnclusion Preliminary study results show that artesunate used for clinical treatment of advanced RB has certain curative effect without extra side effects.

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retinoblastoma / artesunate / curative effect / safety

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ZHANG Yuanyuan, MIAO Lixia, SUN Yanfeng, WANG Jun, LI Yanshan, LIU Hongyan, YUAN Hailian, ZHANG Xianglan,YANG Xinji, LIU Qiuling. Clinical effect and safety of artesunate in treatment of advanced retinoblastoma[J]. Medical Journal of the Chinese People Armed Police Forces. 2015, 26(7): 712-715

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