Objective To evaluate the effectiveness of Qingrejiedutouzhenfang on treatment of measles. Methods Taking prospective, randomized, controlled, open approach, we divided patients into control group(group A,n=30), Qingrejiedutouzhenfang group(group B,n=30) and banlangen (isatis root) group(group C,n=30), and observed clinical effectiveness, complications and adverse reaction incidence. Results Hospitalization time in group B was shorter than that in other two groups(P<0.05). The heating time after treating of group B was shorter than that in group A(P<0.01). The time of fever abatement in group B is shortest, but there was no statistically significant difference among the three groups. One week after treatment, cure rate and effective rate in group A were 53.3% and 73.3%, respectively; cure rate and effective rate in group B were 78.6% and 96.4%, respectively; cure rate and effective rate in group C were 65.5% and 86.2%, respectively. There were statistically significant differences in cure rate and effective rate(P=0.047) among the three groups. Conclusions Qingrejiedutouzhenfang is effective and safe in treatment of measles, and worthy of clinical promotion.