Effects of sodium butyrate acid on kidney blood flow and microvascular permeability in rats with severe scald injury

TANG Fubo; GUO Jing; ZHENG Jinguang; BAI Xiaodong

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Medical Journal of the Chinese People Armed Police Forces ›› 2016, Vol. 27 ›› Issue (1) : 8-11.

Orignal Article

Effects of sodium butyrate acid on kidney blood flow and microvascular permeability in rats with severe scald injury

TANG Fubo^1,3, GUO Jing², ZHENG Jinguang¹, BAI Xiaodong¹

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Abstract

Objective To investigate the protective effects of sodium butyrate on kidney of rats following 50%TBSA full-thickness burns. Methods 48 SD rats, weighing 250~270g, were randomly divided into three groups: sham group, scald group, sodium butyrate group (n=16 each). Rats were subjected to 50% TBSA third-degree burns by immersing the back for 15 seconds and the abdomen for 8 seconds in 100 ℃ water. The sham group was immersed in 37 ℃ water instead. Then 1ml sodium butyrate (400 mg/kg) or 1ml normal saline was intraperitoneally injected, respectively. Renal blood flow was measured by Doppler 3 and 6 hours after injury. Blood were drawn from the heart at 3 and 6 hours after injury for measurement of plasma creatinine (Cr); then the rats were sacrificed and kidney tissues were harvested for the measurement of microvascular permeability and the changes in tissue water content. Results Compared with scald group, the level of Cr and the rate of tissue water in sodium butyrate group were significantly lower at 3 and 6 hours after scald injury(all P<0.05); the microvascular permeability in sodium butyrate group was lower than in scald group at 6 hours after injury(all P<0.05), but had no significant difference at 3 hours after injury(P>0.05). In addition, sodium butyrate significantly increased the RBF level induced by scald injury at 3 and 6 hours(all P<0.05). Conclusion Sodium butyrate has significant protective effects on kidney by increaseing the RBF and inhibiting vasopermeability and tissue edema in rats with lethal scald injury.

Key words

sodium butyrate / scald injury / kidney / histone deacetylase inhibitors

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TANG Fubo, GUO Jing, ZHENG Jinguang, BAI Xiaodong. Effects of sodium butyrate acid on kidney blood flow and microvascular permeability in rats with severe scald injury[J]. Medical Journal of the Chinese People Armed Police Forces. 2016, 27(1): 8-11

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