Non-conjunctival primary ocular adnexal mucosa associated lymphoid tissue lymphoma(POAML) treated with primary radiotherapy

ZHAO Shuixi; YU Liquan; BU Jie; CAO Jingxu; and XIAO Lihua

PDF(591 KB)

Medical Journal of the Chinese People Armed Police Forces ›› 2016, Vol. 27 ›› Issue (12) : 1249-1252.

Non-conjunctival primary ocular adnexal mucosa associated lymphoid tissue lymphoma(POAML) treated with primary radiotherapy

ZHAO Shuixi¹, YU Liquan¹, BU Jie¹, CAO Jingxu¹, and XIAO Lihua²

Author information +

History +

Abstract

Objective To evaluate the dose response of patients with ⅠE stage non-conjunctival primary ocular adnexal mucosa associated lymphoid tissue lymphoma(POAML) treated with primary radiotherapy.Methods Clinical data on thirty-three patients(42 eyes) with stage Ⅰnon-conjunctival POAML treated between November 2003 and Match 2012 were retrospectively studied.Results For all the patients, the local control rate was 100% at the dose of 18 Gy and 27 Gy, while the response rate was 31% and42.9%(P=0.258)respectively as measured with the WHO criteria. However, the response rate was 28.6% and38.1%(P=0.355)respectively as measured with the RECIST criteria. For patients of non-conjunctival POAML treated at the dose of ≥30.6 Gy and 27 Gy, the five-year overall survival(OS) rate was 100% and 95.7% respectively (P=0.8578), and the five-year progression-free survival(PFS) rate was 83.3% and 91.1% respectively (P=0.6497).Conclusions The prescribed dose of 27 Gy for non-conjunctival POAML seems to be effective. Prospective clinical studies should be carried out to define the optimal dose for POAML.

Key words

mucosa associated lymphoid tissue lymphoma / ocular adnexal lymphomas / radiation therapy / dose response

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

ZHAO Shuixi, YU Liquan, BU Jie, CAO Jingxu, and XIAO Lihua. Non-conjunctival primary ocular adnexal mucosa associated lymphoid tissue lymphoma(POAML) treated with primary radiotherapy[J]. Medical Journal of the Chinese People Armed Police Forces. 2016, 27(12): 1249-1252

References

[1] Lazzarino M, Morra E, Rosso R, et al. Clinicopathologic and immunologic characteristics of non Hodgkin’s lymphoma presenting in the orbit[J]. Cancer,1985,55(9):1907-1912.
[2] Bairey O, Kremer I, Rakowsky E, et al. Orbital and adnexal involvement in systemic non-Hodgkin’s lymphoma[J]. Cancer,1994,73(9):2395-2399.
[3] Freeman C, Berg J W, Cutler S J. Occurrence and prognosis of extranodal lymphomas[J]. Cancer,1972,29(1):252-260.
[4] White W L,Ferry J A,Harris N L,et al.Ocular adnexal lymphoma: a clinicopathologic study with identi cation of lymphomas of mucosa-associated lymphoid tissue type[J].Ophthalmology,1995,102(12):1994-2006.
[5] McKelvie P A, McNab A, Francis I C, et al. Ocular adnexal lymphoproliferative disease: a series of 73 cases[J].Clin Experiment Ophthalmol,2001,29(6):387-393.
[6] Meunier J, Lumbroso-Le Rouic L, et al. Ophthalmologic and intraocular non-Hodgkin’s lymphoma: a large single centre study of initial characteristics, natural history, and prognostic factors[J]. Hematol Oncol,2004,22(4):143-158.
[7] Ferry J A, Fung C Y, Zukerberg L, et al. Lymphoma of the ocular adnexa: a study of 353 cases[J]. Am J Surg Pathol,2007,31(2):170-184.
[8] Nakata M, Matsuno Y, Katsumata N, et al. Histology according to the Revised European-American Lymphoma Classification significantly predicts the prognosis of ocular adnexal lymphoma[J]. Leuk Lymphoma,1999,32(5-6):533-543.
[9] Mannami T,Yoshino T, Oshima K, et al. Clinical, histopathological, and immunogenetic analysis of ocular adnexal lymphoproliferative disorders: characterization of MALT lymphoma and reactive lymphoid hyperplasia[J]. Mod Pathol,2001,14(7):641-649.
[10] Cho E Y, Han J J, Ree H J, et al. Clinicopathologic analysis of ocular adnexal lymphomas: extranodal marginal zone B-cell lymphoma constitutes the vast majority of ocular lymphomas among Koreans and affects younger patients[J]. Am J Hematol,2003,73(2):87-96.
[11] Lee J L, Kim M K, Lee K H, et al. Extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue type of the orbit and ocular adnexa[J]. Ann Hematol, 2005,84(1):13-18.
[12] Woo J M, Tang C K, Rho M S, et al. The clinical characteristics and treatment results of ocular adnexal lymphoma[J]. Korean J Ophthalmol,2006,20(1):7-12.
[13] Yoon J S,Ma K T,Kim S J,et al.Prognosis for patients in a Korean population with ocular adnexal lymphoproliferative lesions[J].Ophthal Plast Reconstr Surg,2007,23(2):94-99.
[14] Le Q T, Eulau S M, George T I, et al. Primary radiotherapy for localized orbital MALT lymphoma[J]. Int J Radiat Oncol Biol Phys,2002,52(3): 657-663.
[15] Tsang R W, Gospodarowicz M K, Pintilie M, et al. Localized mucosa-associated lymphoid tissue lymphoma treated with radiation therapy has excellent clinical outcome[J]. J Clin Oncol,2003,21(22):4157-4164.
[16] Fung C Y, Tarbell N J, Lucarelli M J, et al. Ocular adnexal lymphoma: clinical behavior of distinct world health organization classification subtypes[J]. Int J Radiat Oncol Biol Phys,2003,57(5): 1382-1391.
[17] Hasegawa M, Kojima M, Shioya M, et al. Treatment results of radiotherapy for malignant lymphoma of the orbit and histopathological review according to the WHO classification[J]. Int J Radiat Oncol Biol Phys,2003,57(1):172-176.
[18] Uno T, Isobe K, Shikama N, et al. Radiotherapy for extranodal, marginal zone, B-cell lymphoma of mucosa-associated lymphoid tissue originating in the ocular adnexa. A multiinstitutional, retrospective review of 50 patients[J]. Cancer,2003,98(4):865-871.
[19] Lee J L, Kim M K, Lee K H, et al. Extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue-type of the orbit and ocular adnexa[J]. Ann Hematol,2005,84(1):13-18.
[20] Aviles A, Neri N, Calva A, et al. Addition of a short course of chemotherapy did not improve outcome in patients with localized marginal B-cell lymphoma of the orbit[J]. Oncology,2006,70(3):173-176.
[21] Suh C O, Shim S J, Lee S W, et al. Orbital marginal zone B-cell lymphoma of MALT: radiotherapy results and clinical behavior[J]. Int J Radiat Oncol Biol Phys, 2006,65(1):228-233.
[22] Ejima Y,Sasaki R,Okamoto Y,et al.Ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiotherapy[J].Radiother Oncol,2006,78(1):6-9.
[23] Yamashita H,Nakagawa K,Asari T,et al.Radiotherapy for 41 patients with stages I and II MALT lymphoma: a retrospective study[J].Radiother Oncol,2008,87(3):412-417.
[24] Nam H,Ahn Y C,Kim Y D,et al.Prognostic significance of anatomic subsites:results of radiation therapy for 66 patients with localized orbital marginal zone B cell lymphoma[J].Radiother Oncol,2009,90(2):236-241.
[25] Son S H, Choi B O, Kim G W, et al. Primary radiation therapy in patients with localized orbital marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) [J]. Int J Radiat Oncol Biol Phys,2010,77(1):86-91.
[26] Hata M, Omura M, Koike I, et al. Treatment effects and sequelae of radiation therapy for orbital mucosa-associated lymphoid tissue lymphoma[J]. Int J Radiat Oncol Biol Phys, 2011,81(5):1387-1393.
[27] Goda J S, Le L W, Lapperriere N J, et al. Localized orbital mucosa-associated lymphoma tissue lymphoma managed with primary radiation therapy: efficacy and toxicity[J]. Int J Radiat Oncol Biol Phys,2011,81(4):e659-666.
[28] Hashimoto N, Sasaki R, Nishimura H, et al. Long-term outcome and patterns of failure in primary ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiotherapy[J]. Int J Radiat Oncol Biol Phys,2012,82(5): 1509-1514.
[29] Ohja S, Nakamura K, Shioyama Y, et al. Treatment outcome of radiotherapy for localized primary ocular adnexal MALT lymphoma-prognostic effect of the AJCC Tumor-Node-Metastasis clinical staging system[J].Anticancer Res,2015,35(6):3591-3597.
[30] Jung S K, Paik J S, Jung S E, et al. Suggestion of response evaluation criteria in patients with ocular adnexal mucosa-associated lymphoid tissue lymphoma (OAML) [J]. Ann Hematol,2015,94(7):1185-1193
[31] Gayed I, Eskandari M F, McLaughlin P, et al. Value of positron emission tomography in staging ocular adnexal lymphomas and evaluating their response to therapy[J]. Ophthalmic Surg Lasers Imaging,2007,38(4):319-325.
[32] Harada K, Murakami N, Kitaguchi M, et al. Localized ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiation therapy: a long-term outcome in 86 patients with 104 treated eyes[J]. Int J Radiat Oncol Biol Phys,2014,88(3):650-654.