Effect of GFR and UAC to evaluate renal function in patients with type 2 diabetes

FU Ting; LI Jinghua; QI Yue; and WANG Suli

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Medical Journal of the Chinese People Armed Police Forces ›› 2016, Vol. 27 ›› Issue (3) : 233-236.

ORIGINAL ARTICLES

Effect of GFR and UAC to evaluate renal function in patients with type 2 diabetes

FU Ting¹,LI Jinghua¹,QI Yue²,and WANG Suli¹

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Abstract

Objective Through the analysis of glomerular filtration rate (GFR) and urinary albumin concentration (UAC) in 110 patients with type 2 diabetes, to discuss whether there is relevance between GFR and UAC in patients with type 2 diabetes and its application value. Methods One hundred and ten patients with type 2 diabetes were enrolled in this study. All of the patients received measurement of morning urine trace albumin concentration, and renal dynamic imaging examination. General clinical data were collected. Results UAC value was negatively related to GFR value(P<0.05).When GFR<60 ml/(min·1.73 m²), with GFR value as the gold standard, ROC curves showed that the optimal UAC value cut-off values were 10.90 mg/L by maximizing the sum of sensitivity and specificity. In GFR≥60 ml/(min·1.73 m²)group,the incidence of hypertension in patients with normal UAC value was higher than that in UAC abnormal patients(P<0.05). Conclusions In patients with type 2 diabetes, by the rise of UAC value,GFR value would come down. To some extent, UAC value can reflect the renal function changes in patients,but the evaluation of renal function in patients with type 2 diabetes should not be based on the traditional standard (UAC<30 mg/L)as the boundary, in some patients GFR value decreased obviously [GFR < 60 ml/(min·1.73 m²)] wheras UAC value can still be in a normal level. We need to focus on albuminuria and glomerular filtration rate at the same time in the clinical work in patients with type 2 diabetes especially in elderly patients with a history of high blood pressure in order to avoid misdiagnosis or missed diagnosis.

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urinary albumin concentration / glomerular filtration rate / type 2 diabetes / diabetic kidney disease

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FU Ting,LI Jinghua,QI Yue,and WANG Suli. Effect of GFR and UAC to evaluate renal function in patients with type 2 diabetes[J]. Medical Journal of the Chinese People Armed Police Forces. 2016, 27(3): 233-236

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